NEW CONTROLLED RELEASE ANTIBIOTIC DELIVERY SYSTEMS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 1437
Amount: $222,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1987
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Membrane Technology & Research
1030 Hamilton Court, Menlo Park, CA, 94025
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Richard W. Baker
 President
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE DEVELOPMENT OF A CONTROLLED RELEASE SYSTEM TO DELIVER ANTIBIOTIC DRUGS TO THE PERIODONTAL POCKET IS PROPOSED. THIS SYSTEM COULD RESULT IN IMPROVED TREATMENT OF PERIODONTAL DISEASE. THE SYSTEM CONSISTS OF ANTIBIOTIC CONTAINING MICROPARTICLES, 100 IN DIAMETER, FORMULATED AS A SUSPENSION IN A CARRIER MEDIA. ONE FORMULATION, TO BE USED IN THE DENTAL OFFICE, WOULD BE FORMULATED IN A PASTE. THIS PASTE WOULD BE PLACED IN THE PERIODONTAL POCKET BY THE DENTIST, USING A SYRINGE AND THIN RUBBER TUBE. THE MICROPARTICLES IN THE PASTE WOULD RELEASE THE ANTIBIOTIC FOR A TWO TO FOUR WEEK PERIOD, AFTER WHICH RESIDUAL PASTE WOULD BE REMOVED OR REPLACED WITH FRESH MATERIAL. THE SECOND FORMULATION WOULD BE APPLIED BY PERIODONTAL PATIENTS. THE MICROPARTICLES IN THIS FORMULATION WOULD RELEASE THE ANTIBIOTIC FOR ONE TO THREE DAYS. THESE MICROPARTICLES WOULD BE FORMULATED IN A CREAM SUSPENSION AND WOULD BE RUBBED OVER THE GUMS BY THE PATIENT DAILY. A FRACTION OF THE PARTICLES APPLIED WOULD LODGE IN THE PERIODONTAL POCKET OR TEETH CREVICES, WHILE THE REMAINDER WOULD BE REMOVED BY A MOUTH RINSE. BOTH FORMULATIONS WOULD CONTROL ANTIBIOTIC RELEASE BY SLOW DIFFUSION THROUGH A SUITABLE MICROPARTICLE MATRIX POLYMER.

* information listed above is at the time of submission.

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