VOLATILE MARKERS OF PULMONARY TUBERCULOSIS IN THE BREATH

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43AI052504-01
Agency Tracking Number: AI052504
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2002
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
MENSSANA RESEARCH, INC.
MENSSANA RESEARCH, INC., 1 HORIZON RD, STE 1415, FORT LEE, NJ, 07024
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 MICHAEL PHILLIPS
 (201) 886-7004
 MENSSANA@BELLATLANTIC.NET
Business Contact
 MICHAEL PHILLIPS
Phone: (718) 876-2428
Email: MENSSANA@BELLATLANTIC.NET
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): Background: Pulmonary tuberculosis (TB) is a growing public health problem, and detection is often costly and time-consuming. A breath test for volatile markers of Mycobacteria could provide a new test for the disease. An advanced new breath test routinely detects volatile organic compounds (VOCs) in breath in picomolar (10-12 mol/l) concentrations. M. tuberculosis manufactures volatile fatty acids and other volatile metabolites; detection of these VOCs in breath could provide an accurate, rapid, inexpensive and non-invasive new marker of infection in patients with active pulmonary TB. Experimental plan: In vitro study: Volatile metabolites in cultures of M. tuberculosis will be identified by gas chromatography and mass spectroscopy. Human study: In patients evaluated for suspected pulmonary TB, breath VOCs will be compared in those with and without disease. The sensitivity, specificity, and positive and negative predictive values of the breath test will be determined. Long term aims: a. Scientific: To determine the diagnostic accuracy of breath markers of M. tuberculosis. b. Technical: to develop a comparatively inexpensive miniaturized and rapid breath test suitable for clinical use and in less developed countries. c. Commercial: To obtain Food and Drug Administration (FDA) approval of the device and market it.

* information listed above is at the time of submission.

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