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A Normal Paradigm to Monitor Perinatal Asphyxia Using A Combined Ultrasound-Neuromodulation and Photoacoustic-Imaging Device

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41EB033751-01
Agency Tracking Number: R41EB033751
Amount: $300,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIBIB
Solicitation Number: PA21-262
Solicitation Year: 2021
Award Year: 2022
Award Start Date (Proposal Award Date): 2022-09-23
Award End Date (Contract End Date): 2023-08-31
Small Business Information
Sparks, MD 21152-9201
United States
DUNS: 808275890
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (410) 472-2600
Business Contact
Phone: (936) 588-6901
Research Institution
BALTIMORE, MD 21218-2680
United States

 Nonprofit College or University

PROJECT SUMMARYThe Brimrose Technology Corporation and partner, The Johns Hopkins University, propose
using non-invasive ultrasound neuromodulation to identify hypoxic-ischemic encephalopathy (HIE) in
newborns to reduce death and lifelong brain injury. HIE is the leading cause of neonatal death and
impacts 2-6 of every 1,000 live births in the developed world. Our goal is to investigate and demonstrate
the effect of graded hypoxia and repeated oxygen/glucose deprivation on neural response using
ultrasound modulation. We will then develop and validate an ultrasound-neuromodulation coupled with
photoacoustic-imaging device prototype to monitor neonatal brain injury. This device will be used for
early diagnosis of HIE to enable timely intervention, which minimizes long-term disability. The two
organizations have established a strong research team and joint operating lab at Hopkins to develop
this system. Due to various limitations of current methods, there is an urgent need for an early HIE
diagnostic kit to enable prompt therapeutic interventions. There are no early diagnostic procedures or
devices available in the clinic for HIE. Hence, our proposal addresses a critical unmet need.Narrative
Developing technologies for early diagnosis of hypoxic-ischemic encephalopathy (HIE) is an unmet clinical need.
We propose to use non-invasive ultrasound neural stimulation coupled with photoacoustic imaging to assess
brain injury. Our proposal enables early detection of brain injury within few hours of birth for the first time
facilitating timely intervention. Early intervention is critical for minimizing long-term brain damage due to HIE.

* Information listed above is at the time of submission. *

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