THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DEVELOP AND COMMERCIALIZE MODIFIED POLYNUCLEOTIDES AS ANTICANCER AND ANTIVIRAL DRUGS.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4759
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Western Ny Technology Dev Cen, 2211 Main Street, Buffalo, NY, 14214
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 YAU-KWAN HO
 PRINCIPAL INVESTIGATOR
 (716) 831-3638
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DEVELOP AND COMMERCIALIZE MODIFIED POLYNUCLEOTIDES AS ANTICANCER AND ANTIVIRAL DRUGS. POLY(I)MERCAPTOPOLY(C) IS SUPERIOR TO THE WELL-KNOWN INTERFERON INDUCER POLY(I)POLY(C). IN ITS ANTI- PROLIFERATIVE EFFECTS AGAINST HUMAN TUMOR CELLS, AS WELL AS IN ITS INTERFERON INDUCING ACTIVITY. FURTHERMORE, POLY(I) MPC IS LESS TOXIC IN ANIMALS THAN THE UNMODIFIED POLY(I) POLY(C). THUS, THE POTENTIAL OF POLY(I)MPC AS A USEFUL ANTITUMOR AND ANTIVIRAL DRUG IS GOOD. HOWEVER, USING PRESENT TECHNOLOGY, IT COSTS $2,000 TO PRODUCE ONE GRAM OF POLY(I)MPC. A SPECIFIC AIM OF THIS GRANT APPLICATION IS TO DEVELOP A METHOD TO PRODUCE MPC, AND THUS POLY(I)MPC, LESS EXPENSIVELY, MAKING LARGER QUANTITIES OF POLY(I)MPC AFFORDABLE FOR PRECLINICAL AND CLINICAL TESTING. IT IS PROPOSED THAT THE STARTING MATERIALS, POLY(I) AND POLY(C), WILL BE PREPARED USING AN IMMOBILIZED ENZYME SYSTEM AND THATTHE THIOLATION OF POLY(C) IN A BUFFERED AQUEOUS SOLUTION WILL BE DEVELOPED AND SCALED-UP TO CUT LABOR COST. ANOTHER SPECIFIC AIM IS TO CONFIRM THE IN VIVO ANTITUMOR ACTIVITIES OF POLY(I)MPC AND OF MPC. FAVORABLE RESULTS SHOULD LEAD TO LONGER-TERM OBJECTIVES, WHICH WOULD INCLUDE DEVELOPMENT OF OTHER MERCAPTOPOLYNUCLEOTIDES, SCALE-UP AND PRODUCTION FOR BIOLOGICAL AND CLINICAL STUDIES, AND SUBSEQUENT COMMERCIALIZATION.

* Information listed above is at the time of submission. *

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