PROCUREMENT OF PRIMARY REFERENCE MATERIALS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 5017
Amount: $248,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1987
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
2448 Sixth Street, Berkeley, CA, 94710
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Robert S Ward
 Principal Investigator
 (415) 849-0452
Business Contact
Phone: () -
Research Institution
N/A
Abstract
POLYURETHANES ARE USED IN A VARIETY OF BIOMEDICAL DEVICES, INCLUDING ARTIFICIAL HEARTS, VASCULAR GRAFTS AND CATHETERS, AND INTRA-AORTIC BALLOONS. THIS RESEARCH PRESENTS METHODS FOR SYNTHESIS, CHARACTERIZATION, AND FABRICATION OF POLY- URETHANEUREA (PUU) PRIMARY REFERENCE MATERIALS (PRM). THE PROGRAM INVOLVES THE SYNTHESIS OF A SINGLE LOT OF ADDITIVE- FREE POLYMER FOLLOWED BY THOROUGH CHARACTERIZATION OF THE BULK AND SURFACE PROPERTIES OF CAST FILMS. THE PUU WILL BE CONVERTED INTO TUBE AND SHEET CONFIGURATIONS UNDER CONTROL- LED AND DOCUMENTED CONDITIONS. BULK AND SURFACE PHYSIO- CHEMICAL CHARACTERIZATION WILL BE APPLIED TO ASSESS CHANGES INDUCED BY THE CONVERSION PROCESS, PACKAGING, AND STERILIZA-TION. A DOCUMENTATION PACKAGE WILL BE PROVIDED WITH THE PRMTHAT WILL CONTAIN THE CHARACTERIZATION RESULTS AND HANDLING AND STORAGE INSTRUCTIONS. DURING PHASE I, A LOT OF POLY- TETRAMETHYLENE (PTMO)-BASED PUU WILL BE SYNTHESIZED AND CHARACTERIZED. PILOT QUANTITIES OF PRM IN SHEET AND TUBING CONFIGURATIONS WILL BE FABRICATED TO ASSESS THE FEASIBILITY OF USING PUU AS REFERENCE MATERIALS. STERILE, PACKAGED SAMPLES WILL BE CHARACTERIZED TO DETERMINE THE EFFECT OF GAMMA RADIATION AND TO ASSESS TIME-DEPENDENT SURFACE CHANGESIN THE PRM. DURING PHASE II, PRM WILL BE FABRICATED FROM POLYETHYLENE OXIDE (PEO)-BASED PUU AND POLYDIMETHYLSILOXANE (PSX)-CONTAINING PUU TO PROVIDE PRM WITH A RANGE OF SURFACE FREE ENERGIES/HYDROPHOBICITIES. STERILE, PACKAGED SAMPLES OF THESE MATERIALS WILL BE CHARACTERIZED. SELECTED CHARAC- TERIZATION WILL BE CONDUCTED AT REGULAR INTERVALS TO DETERMINE IF THE BULK OR SURFACE PROPERTIES OF THE PRM HAVE AFFECTED BY STORAGE.

* Information listed above is at the time of submission. *

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