INTEGRATING TRANSIENT RECORDER FOR TOF MASS SPECCTROMETRY

Award Information
Agency:
Department of Health and Human Services
Branch:
N/A
Amount:
$500,000.00
Award Year:
1992
Program:
SBIR
Phase:
Phase II
Contract:
N/A
Agency Tracking Number:
16830
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Meridian Instruments Inc.
2310 Science Pky, Okemos, MI, 48864
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
N/A
Principal Investigator
 Peter Burrill
 (517) 349-7200
Business Contact
Phone: () -
Research Institution
N/A
Abstract
MASS SPECTROMETRY (MS) COMBINED WITH GAS CHROMATOGRAPHY, (GC) IS THE MOST POWERFUL TECHNIQUE AVAILABLE FOR IDENTIFYING BIOACTIVE COMPOUNDS AND FOR THE SELECTIVE DETECTION OF DRUG METABOLITES. RECENT IMPROVEMENTS IN GC RESOLUTION HAVE SURPASSED INCREASES IN THE SPEED AND SENSITIVITY OF MS, THUS PREVENTING THIS WIDELY-USED COMBINATION FROM ACHIEVING ITS FULL POTENTIAL. TIME-OF-FLIGHT MS (TOFMS), COMBINED WITH HIGH-SPEED, HIGH-EFFICIENCY INTEGRATING TRANSIENT RECORDER (ITR) BUILT AT MICHIGAN STATE UNIVERSITY (MSU) HAS BEEN SUCCESSFULLY APPLIED TO GC-TOFMS. HOWEVER, THE MSU-ITR IS BASED ON CUMBERSOME AND SOMEWHAT ESOTERIC HIGH-SPEED ELECTRONICS. THIS PHASE I GRANT WILL DETERMINE THE FEASIBILITY OF A NOVELAND MUCH SIMPLER ITR DESIGN AND, HENCE, A COMMERCIALLY VIABLE GC-TOFMS-ITR INSTRUMENT FOR ENHANCED BIOANALYTICAL CAPABILITIES. A GREATLY SIMPLIFIED ITR DESIGN, WHICH USES "MASS-MAPPED ACQUISITION" TO REDUCE THE REQUIRED DATA ACQUISITION RATE WITHOUT LOSS OF TIME (MASS) RESOLUTION, WILL BE DEVELOPED. EACH SECOND, UP TO 40 SCAN FILES WILL BEPRODUCED BY SUMMING 125 TO 5,000 TOF TRANSIENTS. IN PHASE II, THIS ITR WILL BE INTEGRATED WITH A NOVEL TIME-OF-FLIGHT MASS SPECTROMETER TO PROVIDE UNIT MASS RESOLUTION IN THE RANGE FROM 1 TO 1,000MU AND A SENSITIVITY, FOR 40 COMPLETE MASS SPECTRA PER SECOND, COMPARABLE TO THAT ACHIEVED PRESENTLY ONLY BY SELECTED-ION MONITORING TECHNIQUES. MASS SPECTROMETRY (MS) COMBINED WITH GAS CHROMATOGRAPHY, (GC) IS THE MOST POWERFUL TECHNIQUE AVAILABLE FOR IDENTIFYING BIOACTIVE COMPOUNDS AND FOR THE SELECTIVE DETECTION OF DRUG METABOLITES. RECENT IMPROVEMENTS IN GC RESOLUTION HAVE SURPASSED INCREASES IN THE SPEED AND SENSITIVITY OF MS, THUS PREVENTING THIS WIDELY-USED COMBINATION FROM ACHIEVING ITS FULL POTENTIAL. TIME-OF-FLIGHT MS (TOFMS), COMBINED WITH HIGH-SPEED, HIGH-EFFICIENCY INTEGRATING TRANSIENT RECORDER (ITR) BUILT AT MICHIGAN STATE UNIVERSITY (MSU) HAS BEEN SUCCESSFULLY APPLIED TO GC-TOFMS. HOWEVER, THE MSU-ITR IS BASED ON CUMBERSOME AND SOMEWHAT ESOTERIC HIGH-SPEED ELECTRONICS. THIS PHASE I GRANT WILL DETERMINE THE FEASIBILITY OF A NOVELAND MUCH SIMPLER ITR DESIGN AND, HENCE, A COMMERCIALLY VIABLE GC-TOFMS-ITR INSTRUMENT FOR ENHANCED BIOANALYTICAL CAPABILITIES. A GREATLY SIMPLIFIED ITR DESIGN, WHICH USES "MASS-MAPPED ACQUISITION" TO REDUCE THE REQUIRED DATA ACQUISITION RATE WITHOUT LOSS OF TIME (MASS) RESOLUTION, WILL BE DEVELOPED. EACH SECOND, UP TO 40 SCAN FILES WILL BEPRODUCED BY SUMMING 125 TO 5,000 TOF TRANSIENTS. IN PHASE II, THIS ITR WILL BE INTEGRATED WITH A NOVEL TIME-OF-FLIGHT MASS SPECTROMETER TO PROVIDE UNIT MASS RESOLUTION IN THE RANGE FROM 1 TO 1,000MU AND A SENSITIVITY, FOR 40 COMPLETE MASS SPECTRA PER SECOND, COMPARABLE TO THAT ACHIEVED PRESENTLY ONLY BY SELECTED-ION MONITORING TECHNIQUES.

* information listed above is at the time of submission.

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