BRAIN TEMPERATURE MONITORING IN NEONATES (PHASE II)

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 2R44HD048138-02A2
Agency Tracking Number: HD048138
Amount: $370,519.00
Phase: Phase II
Program: SBIR
Awards Year: 2007
Solicitation Year: 2007
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
MERIDIAN MEDICAL SYSTEMS, LLC
MERIDIAN MEDICAL SYSTEMS, LLC, 77 GOOSE COVE LN, WOOLWICH, ME, 04579
DUNS: 145080961
HUBZone Owned: Y
Woman Owned: Y
Socially and Economically Disadvantaged: Y
Principal Investigator
 KENNETH CARR
 (207) 443-6636
 KEN@MMS-LLC.COM
Business Contact
 KENNETH CARR
Phone: (207) 443-6636
Email: ken@mms-llc.com
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): Hypoxic-ischemic encephalopathy (HIE) represents a serious problem in newborns, occurring in 3-9 of every 1,000 term infants, with about half of these HIE babies dying or suffering life-long severe handicaps, such as mental retardation or cerebral palsy. Current efforts to reduce the effects of HIE by hypothermia (cooling) have been hampered by the lack of a reliable noninvasive method of monitoring the infant's brain temperature during the hypothermic treatment, which lasts about 48 hours. The primary objective of this Phase I feasibility study was to evaluate Passive Microwave Radiometry (PMR) for monitoring intracranial temperature in neonates. The Phase I program has been successfully completed. The significant challenge of the overall program occurs in Phase II involving the integration of the radiometric receivers into the transducers and developing the logic and circuitry required to combine the two radiometric outputs to determine temperature at depth. The goal of the Phase II program is to develop an affordable system for the reliable and continuous monitoring of intracranial temperature in neonates. 7. Project Narrative Two to four of every 1000 babies delivered in the United States experience an obstetrical complication resulting in asphyxial injury to the brain leading to the development of cerebral palsy, mental retardation or even death. Recent clinical studies have shown that hypothermia decreases the injured brain's metabolism and oxygen requirements, and can significantly decrease the chances of physical disability and death. Although promising, hypothermia is an evolving therapy and there is much to learn regarding the optimal degree and duration of hypothermia. Knowledge of exact brain temperature is needed before these important questions can be adequately answered.

* information listed above is at the time of submission.

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