Highly bright and narrow emitting nanocrystal fluoreagents for multiplexed detect

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
2007
Program:
SBIR
Phase:
Phase I
Contract:
1R43GM081952-01
Award Id:
85734
Agency Tracking Number:
GM081952
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
MESOLIGHT, LLC, 4301 W Markham St #831, LITTLE ROCK, AR, 72205
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
155828861
Principal Investigator:
YUNJUN WANG
(479) 799-3368
YJWANG@MESOLIGHT.COM
Business Contact:
YUNJUN WANG
() -
yjwang@mesolight.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): Fluorescence-based multiplexed detection and spectroscopy is finding more and more applications in analytical chemistry, molecular biology, and medical diagnostics. For example, rapid advance in genomics and proteomics research has elucidated the availability of multiple biomarkers, of which simultaneous detection allow diagnosing the complex diseases such as cancer with significantly improved accuracy in comparison with the single marker detection. Rapid, sensitive and simultaneous detection of multiple pathogens in food, in water, and in air, is essential to ensure public safety and to protect the public against potential bioterrorism. In the modern structural biology, simultaneously probing the change in distances betw een different sites within a larger biomolecule such as multi-subunit proteins would provide valuable information that can be utilized for the development of rational drug design and rapid vaccine development for chemical and biological countermeasures. Wh ile, the availability of high quality fluoreagents with the high and distinguished fluorescent emission is the prerequisite for all above-mentioned applications. This NIH SBIR program will develop a series of alloyed tertiary semiconductor nanocrystals tha t have highly bright, stable, and narrow emission, are readily to be bio-conjugated with biomolecules such as proteins and DNA, and thus can be ideally be used as fluoreagents in multiplexed detection and spectroscopy.

* information listed above is at the time of submission.

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