Simultaneous Stimulation and Recording in Scalable Microelectrode Arrays

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$1,569,268.00
Award Year:
2010
Program:
SBIR
Phase:
Phase II
Contract:
2R44NS062477-03
Award Id:
89416
Agency Tracking Number:
NS062477
Solicitation Year:
n/a
Solicitation Topic Code:
NINDS
Solicitation Number:
n/a
Small Business Information
AXION BIOSYSTEMS, LLC, 1186 LARCH LN, DECATUR, GA, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
802587035
Principal Investigator:
JAMES ROSS
() -
Business Contact:
JAMES ROSS
() -
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): The proposed study utilizes novel electronics and microfabrication techniques to create scalable, in-vitro Microelectrode Array (MEA) technologies that conform to industry standards for multiwell plates. This research w ill not only enable rapid advancements in the study of network-level electrophysiology, but it will also create new opportunities for pharmaceutical research and toxicity screening. This Phase II proposal involves two significant developments for neurologi cal research. Specifically, Aim 1 builds on the scalable simultaneous stimulation and recording Integrated Circuit (IC) developed in Phase I to produce a full electronics platform for capturing, processing and storing electrophysiological information. Amon g its many advantages, this electronics platform will recover signals traditionally obscured by stimulation artifacts. This captured data, combined with the ability to simultaneously manage 768 microelectrodes and automate experimental protocols, will prov ide new measures of single-cell and network-level neural activity. Aim 2 will produce scalable, inexpensive, and flexible processes for fabricating multiwell MEAs that, in conjunction with the electronics developed in Aim 1, will yield a high-throughput, n etwork-electrophysiology toolset. PUBLIC HEALTH RELEVANCE: This research uses novel electronic and fabrication technologies to create faster, lower-cost methods for neural research. Ultimately, this development will facilitate medical and scientific discoveries that will benefit the treatment of neural disorders such as Parkinson's disease and epilepsy.

* information listed above is at the time of submission.

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