A 13C-XYLOSE BREATH TEST FOR BACTERIAL OVERGROWTH

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$445,000.00
Award Year:
1994
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
16545
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Metabolic Solutions, Inc.
33 Nagog Park, Acton, MA, 01720
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Wagner, David A
Principal Investigator
(508) 635-9914
Business Contact:
1 R43 DK44399-01
() -
Research Institution:
n/a
Abstract
ANATOMIC AND PHYSIOLOGICAL DERANGEMENTS OF THE GASTROINTESTINAL TRACT CAN LEAD TO ABNORMAL OVERGROWTH OF THE SMALL INTESTINE. A QUANTITATIVE CULTURE OF AN ASPIRATE OF SMALL BOWEL FLUID IS USED TO DETECT BACTERIAL OVERGROWTH. THIS IS OFTEN NOT PERFORMED BECAUSE IT IS SO INCONVENIENT. THE NEED FOR A RELIABLE, NON-INVASIVE SCREENING TEST FOR BACTERIAL OVERGROWTH HAS LED TO THE DEVELOP- MENT OF BREATH TESTS USING RADIOACTIVE 14C SUBSTRATES. A ONE GRAM 14C-XYLOSE BREATH HAS BEEN EXTENSIVELY VALIDATED FOR THE SPECIFIC DIAGNOSIS OF BACTERIAL OVERGROWTH. HOWEVER, BECAUSE THE 14C-XYLOSE BREATH TEST USES A SMALL RADIOACTIVE DOSE OF XYLOSE, ITS USE IN CHILDREN AND PREGNANT WOMEN OR REPEATED USE, DEMANDS DEVELOPMENT OF A NON-RADIOACTIVE ALTERNATIVE TEST. WE WILL DEVELOP A SAFE, NON-RADIOACTIVE, ALTERNATIVE TO THE 14C-XYLOSE TEST USING INSTEAD THE STABLE ISOTOPE 13C. STABLE ISOTOPES SUCH AS 13C EMIT NO RADIATION AND ARE NATURALLY PRESENT IN OUR BODY. THE POTENTIAL COMMERCIAL APPLICATION OF THIS TECHNOLOGICAL INNOVATION IS THE DEVELOPMENT OF A SAFE AND ACCURATE XYLOSE BREATH TEST KIT FOR THE DETECTION OF SMALL BOWEL BACTERIAL OVERGROWTH. THE 13C-XYLOSE BREATH TEST KITS WILL BE EASY TO ADMINISTER IN ANY PHYSICIAN OFFICE AND WILL BE ACCURATE FOR DIAGNOSIS OF BACTERIAL OVERGROWTH.

* information listed above is at the time of submission.

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