A BREATH TEST TO DETECT BACTERIAL OVERGROWTH IN ELDERLY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$830,682.00
Award Year:
2002
Program:
SBIR
Phase:
Phase II
Contract:
2R44DK057339-02
Agency Tracking Number:
DK057339
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
METABOLIC SOLUTIONS, INC.
METABOLIC SOLUTIONS, INC., 460 AMHERST ST, NASHUA, NH, 03063
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DAVID WAGNER
(603) 598-6960
DAVID@METSOL.COM
Business Contact:
MARTIN BAKER
(603) 598-6973
MARTINB@METSOL.COM
Research Institution:
n/a
Abstract
Bacterial overgrowth is a condition found primarily in the elderly and is estimated to affect 33% of people over 65 years. It causes great discomfort and clinically important nutritional deficiencies if left untreated. The underlying cause is reduced gastric acid secretion associated with aging. Management of overgrowth is hampered because low cost and easy to use diagnostic tests do not exist. Detection is meaningful because while the condition is never cured it can be effectively controlled through treatment. Our objective is to develop an easy to use and cost effective test to detect bacterial overgrowth. The clinical utility is the ability to detect the bacteria overgrowth as accurately as the gold standard (jejunal cultures) in patients exhibiting classic disease symptoms but whom ordinarily wouldn't receive expensive and invasive jejunal culture. The test will accurately detect the condition pre- and post-therapy and lead to quality of life improvement. The novelty of this proposal is the use of a non-invasive breath test employing a naturally occurring sugar labeled with carbon-13 as a probe. If overgrowth is present, the bacteria is present, the bacteria in the small intestine metabolize the labeled substrate and high concentrations of (13)CO(2) are expired in the breath. PROPOSED COMMERCIAL APPLICATION: There are 25 million Americans over the age of 65 and they accounted for 10 million physician office visits with complaints of classic overgrowth symptoms The proposed test will significantly reduce national health care expenditures because proper diagnosis will lead to fewer office visits, more prudent use of drugs and better general health and well-being in the elderly.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government