GENERATION OF MAGNETIC RESONANCE IMAGES OF INTRACRANIAL AND EXTRACRANIAL CAROTID ARTERIAL LUMENS, TOGETHER WITH RELATED VOLUME BLOOD FLOW INFORMATION FOR EACH LUMEN, HAS POTENTIAL FOR PROVIDING A NONINVASIVE AND MORE DEFINITIVE TECHNIQUE FOR DIAGNOSIS OF

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
3248
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Metriflow, Inc.
8702 Watertown Plank Road, Milwaukee, WI, 53226
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
RICHARD E. HALBACH
PRINCIPAL INVESTIGATOR
(414) 778-3780
Business Contact:
() -
Research Institution:
n/a
Abstract
GENERATION OF MAGNETIC RESONANCE IMAGES OF INTRACRANIAL AND EXTRACRANIAL CAROTID ARTERIAL LUMENS, TOGETHER WITH RELATED VOLUME BLOOD FLOW INFORMATION FOR EACH LUMEN, HAS POTENTIAL FOR PROVIDING A NONINVASIVE AND MORE DEFINITIVE TECHNIQUE FOR DIAGNOSIS OF INCIPIENT STROKE DUE TO ARTERIAL DISEASE THAN EITHER ULTRASOUND OR ANGIOGRAPHY. TO DEMONSTRATE THIS POTENTIAL, WE PROPOSE TO APPLY A SENSITIVE LINE/FAST PASSAGE SCANNING METHOD, WHICH IS SPECIFICALLY SUITED TO IMAGING AND QUANTIFYING BLOOD IN MOTION RATHER THAN TISSUE AT REST. A CYLINDRICAL RESONANT VOXEL COAXIAL WITH THE LUMEN IS DEFINED BY 2 ROTATING GRADIENT FIELDS AND A FAST PASSAGE ABSORPTION NOTCH. THE PULSATILE, REAL-TIME NMR SIGNAL IS PROPORTIONAL TO BLOOD VOLUME FLOW RATE PER VOXEL AREA AND IS ALREADY IN THE FREQUENCY DOMAIN. THE DATA ARE COMPUTER PROCESSED TO PROVIDE A VIDEO PRESENTATION OF LUMEN SHAPE, A 2-D COLOR-CODED VELOCITY PROFILE, THE PULSE WAVE FORM, AND AVERAGE AND PEAK SYSTOLIC VOLUME FLOW RATES. IN PHASE I, WE PROPOSE TO DEMONSTRATE THE FEASIBILITY OF CAROTID ARTERIAL MEASUREMENTS BY OUR METHOD USING A .15T PERMANENT MAGNET AT THE MEDICAL COLLEGE OF WISCONSIN. GUIDED BY THESE RESULTS, PHASE II WILL BE R&D LEADING TO A UNIT USING A 0.3T PERMANENT MAGNET.

* information listed above is at the time of submission.

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