A Fiber-Optic Evanescent Wave Absorption Organophosphorus Biosensor
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AbstractOrganophosphorous compounds (OPC's) have strongly adverse effects on human health and ecosystems, and reliable monitoring of these compounds is of utmost importance. MetroLaser proposes to develop a fiber-optic evanescent wave mid-IR absorption biosensorfor the detection of OPC's with Acetylcholinesterase (AChE) as the sensing material. The proposed sensor is expected to have superior sensitivity, selectivity, and responsivity. To this end, a porous matrix of ordered multi-layers of AChE-coatednano-particles (Quantum Dots, QD's) provide the sensing region. The controlled formation of a thick porous sensing region containing high surface-to-volume ratio QD's ensures minimal sensor-to-sensor variation, maximum responsivity, as well as enhancedmid-IR absorption, and therefore, a substantial increase in sensitivity. It is estimated that the detection limit of the sensor can be made to be in the pM range. Mid-IR
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