A Fiber-Optic Evanescent Wave Absorption Organophosphorus Biosensor

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$69,966.00
Award Year:
2001
Program:
SBIR
Phase:
Phase I
Contract:
DAAD19-02-C-0033
Award Id:
52965
Agency Tracking Number:
A012-0724
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
18010 Skypark Circle, Suite 100, Irvine, CA, 92614
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
188465819
Principal Investigator:
Bauke Heeg
Senior Scientist
(949) 553-0688
bheeg@metrolaserinc.com
Business Contact:
Peter DeBarber
Vice President
(949) 553-0688
pdebarber@metrolaserinc.com
Research Institute:
n/a
Abstract
Organophosphorous compounds (OPC's) have strongly adverse effects on human health and ecosystems, and reliable monitoring of these compounds is of utmost importance. MetroLaser proposes to develop a fiber-optic evanescent wave mid-IR absorption biosensorfor the detection of OPC's with Acetylcholinesterase (AChE) as the sensing material. The proposed sensor is expected to have superior sensitivity, selectivity, and responsivity. To this end, a porous matrix of ordered multi-layers of AChE-coatednano-particles (Quantum Dots, QD's) provide the sensing region. The controlled formation of a thick porous sensing region containing high surface-to-volume ratio QD's ensures minimal sensor-to-sensor variation, maximum responsivity, as well as enhancedmid-IR absorption, and therefore, a substantial increase in sensitivity. It is estimated that the detection limit of the sensor can be made to be in the pM range. Mid-IR

* information listed above is at the time of submission.

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