A Fiber-Optic Evanescent Wave Absorption Organophosphorus Biosensor

Award Information
Agency: Department of Defense
Branch: Army
Contract: DAAD19-02-C-0033
Agency Tracking Number: A012-0724
Amount: $69,966.00
Phase: Phase I
Program: SBIR
Awards Year: 2001
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
METROLASER, INC.
18010 Skypark Circle, Suite 100, Irvine, CA, 92614
DUNS: 188465819
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Bauke Heeg
 Senior Scientist
 (949) 553-0688
 bheeg@metrolaserinc.com
Business Contact
 Peter DeBarber
Title: Vice President
Phone: (949) 553-0688
Email: pdebarber@metrolaserinc.com
Research Institution
N/A
Abstract
Organophosphorous compounds (OPC's) have strongly adverse effects on human health and ecosystems, and reliable monitoring of these compounds is of utmost importance. MetroLaser proposes to develop a fiber-optic evanescent wave mid-IR absorption biosensorfor the detection of OPC's with Acetylcholinesterase (AChE) as the sensing material. The proposed sensor is expected to have superior sensitivity, selectivity, and responsivity. To this end, a porous matrix of ordered multi-layers of AChE-coatednano-particles (Quantum Dots, QD's) provide the sensing region. The controlled formation of a thick porous sensing region containing high surface-to-volume ratio QD's ensures minimal sensor-to-sensor variation, maximum responsivity, as well as enhancedmid-IR absorption, and therefore, a substantial increase in sensitivity. It is estimated that the detection limit of the sensor can be made to be in the pM range. Mid-IR

* information listed above is at the time of submission.

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