A TECHNOLOGY WILL BE DEVELOPED FOR THE PRODUCTION OF MINIATURE BIOSENSORS THAT CAN BE USED FOR IN VIVO AND IN VITRO MONITORING OF LOW MOLECULAR WEIGHT ANALYTES (<1000) SUCH AS METABOLITES, DRUGS, HORMONES, AND TOXIC SUBSTANCES.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4888
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Michigan Research Corp
2901 Baxter Road, Ann Arbor, MI, 48109
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 EVANGELINE YAP CESAR
 PRINCIPAL INVESTIGATOR
 (313) 764-4118
Business Contact
Phone: () -
Research Institution
N/A
Abstract
A TECHNOLOGY WILL BE DEVELOPED FOR THE PRODUCTION OF MINIATURE BIOSENSORS THAT CAN BE USED FOR IN VIVO AND IN VITRO MONITORING OF LOW MOLECULAR WEIGHT ANALYTES (<1000) SUCH AS METABOLITES, DRUGS, HORMONES, AND TOXIC SUBSTANCES. THE TECHNOLOGY IS BASED ON FIBER OPTICS AND IMMUNOASSAY PRINCIPLES, THAT IS, A RECEPTOR IS SELECTED FOR A DRUG, AND THE QUENCHING OF A FLUORESCENTLY LABELED ANALOG OF THE DRUG IS USED TO MEASURE THE EXTENT OF BINDING BETWEEN RECEPTOR AND DRUG. WHILE IMMUNOASSAYS ARE DISCRETE TESTS, THE BIO- SENSOR TECHNOLOGY BEING DEVELOPED PROVIDES CONTINUOUS ONLINEMONITORING. THE ANTIBODY OR ITS EQUIVALENT AND A HIGH MW FLUORESCENT ANALOG ARE RETAINED IN A SELECTIVELY POROUS MICRO TEST TUBE, FORMED BY A HOLLOW DIALYSIS FIBER (-300 MICRONS DIAMETER). THE BIOSENSOR READILY RESPONDS TO EXTERNAL CONCENTRATION CHANGES OF ANALYTE DUE TO THE REVERSIBLE DISPLACEMENT OF THE FLUORESCENT ANALOG FROM THE RECEPTOR. FLUORESCENT INTENSITY IS MONITORED WITH A SINGLE OPTICAL FIBER INSERTED INTO THE HOLLOW DIALYSIS FIBER. THE USE OF FIBER OPTICS PROVIDES THE CAPABILITY FOR A WIDE VARIETY OF OPTICAL MEASUREMENTS, FOR EXAMPLE, COLORIMETRY, FLUORESCENCE, LIGHT SCATTERING, AND OPTICAL ROTATION, TO MEASURE THE EXTENT OF BINDING. EVENTUALLY, AS MINIATURE OPTIC ELECTRONIC DEVICES (SOLID STATE LASERS, PHOTO- DETECTORS, AND COUPLERS) BECOME AVAILABLE, IMPLANTABLE BIOSENSORS WILL BE PRACTICAL. APPLICATIONS FOR THESE BIOSENSORS INCLUDE: CONTINUOUS DRUG MONITORING IN INTENSIVECARE; FEEDBACK CONTROL SYSTEMS; AND MEASUREMENT OF TOXIC CHEMICALS IN THE ENVIRONMENT.

* information listed above is at the time of submission.

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