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Multimodal optical imager for olfactory dysfunction diagnosis

Award Information
Agency: Department of Defense
Branch: Defense Health Agency
Contract: W81XWH22P0064
Agency Tracking Number: H221-003-0024
Amount: $249,577.06
Phase: Phase I
Program: SBIR
Solicitation Topic Code: DHA221-003
Solicitation Number: 22.1
Solicitation Year: 2022
Award Year: 2022
Award Start Date (Proposal Award Date): 2022-06-02
Award End Date (Contract End Date): 2023-01-01
Small Business Information
20 New England Business Center
Andover, MA 01810-1111
United States
DUNS: 073800062
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Jesung Park
 (978) 738-8134
Business Contact
 William Marinelli
Phone: (978) 738-8226
Research Institution

Physical Sciences Inc., in collaboration with Tufts University and Massachusetts Eye and Ear, proposes to explore the use of an advanced multimodal optical imaging technology for diagnosing olfactory dysfunction (OD). OD is a significant threat factor in the modern military due to frequent exposure to harmful inhalational environments in various military settings. In addition, COVID-19 has caused a sudden onset of OD, and most COVID-19 patients suffer from partial or full OD. Although various olfactory tests have been used to diagnose OD, there is no reliable clinical device to assess OD. The only clinical tool is the nasal endoscope, which has coarse resolution and does not provide any subsurface details. Clearly, more accurate diagnostic methods are required to address the aforementioned issues in the current clinical situations. Our proposed approach is to combine within the same instrument to complementary optical modalities: optical coherence tomography and reflectance confocal microscopy. When combined, they can simultaneously provide real-time, depth-resolved images of the olfactory neuroepithelium and sub-cellular details. Successful development of this technology will help olfactory researchers to better understand dysfunctions in the olfaction process and also enable rhinologists to more accurately diagnose OD.

* Information listed above is at the time of submission. *

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