SPECIFIC ASSAYS FOR FENTANYL DERIVATIVES AND METABOLITES

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 7409
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1987
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Microanalytic Research Inc
23461 Ridge Route Unit H, Laguna Hills, CA, 92653
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 PETER B DEWHURST PHD
 (714) 768-5419
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE LONG-TERM OBJECTIVE OF THIS PROJECT IS THE DEVELOPMENT OF A RAPID QUANTITATIVE ASSAY FOR FENTANYL AND A QUALITATIVEASSAY (SCREEN) FOR FENTANYL AND OTHER NARCOTICS OF THE 4-ANILINOPIPERIDINE SERIES. THE ASSAY WILL BE DEVELOPED WITH THE GOAL OF MEASURING THE DRUGS IN WHOLE BLOOD SPOTTED ON FILTER PAPER, I.E., FINGER-STICK ASSAY. THE PROPOSED METHODOLOGY WILL INITIALLY INVOLVE I(125) IMMUNOASSAY TECHNIQUES, WHICH WILL BE CHANGED LATER TO A SOLID-PHASE ENZYME IMMUNOASSAY PROTOCOL. THE DIRECT BENEFIT TO THE HEALTH FIELD WILL BE THE AVAILABILITY OF A TEST THAT IS RAPID, NONLABOR INTENSIVE, COST EFFECTIVE, AND SPECIFIC FOR THE FENTANYL FAMILY OF DRUGS AND DETECTION OF THEIR ABUSE. THE SPECIMEN EMPLOYED CAN BE OBTAINED AWAY FROM THE LABORATORY BY NONTRAINED PERSONNEL AND CANNOT BE ADULTERATED. FURTHERMORE, IT CAN BE OBTAINED WITHOUT PERSONAL EMBARRASSMENT TO THE INDIVIDUAL BEING TESTED (E.G., BEING OBSERVED PASSING URINE). THE DEVELOPMENT OF THIS TEST WILL MAKE AVAILABLE TO HOSPITALS, DOCTORS' OFFICES, COMMERCIAL LABORATORIES, ANDDRUG-SCREENING CENTERS THE FIRST CONVENIENT, SPECIFIC METHODFOR ASSAYING OR SCREENING FOR THE FENTANYL FAMILY OF DRUGS AND THEIR ABUSE.

* information listed above is at the time of submission.

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