Rapid Assessment of Individual Soldier Operational Readiness

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$100,000.00
Award Year:
2004
Program:
STTR
Phase:
Phase I
Contract:
W911SR-04-P-0098
Agency Tracking Number:
A045-018-0041
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
MICROBIAL INSIGHTS, INC.
2340 Stock Creek Blvd, Rockford, TN, 37853
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
858462625
Principal Investigator:
Edward Sobek
Indoor Air Division Director
(865) 573-8188
esobek@microbe.com
Business Contact:
Greg Davis
President
(865) 573-8188
gdavis@microbe.com
Research Institution:
University of Tennessee
David C White
10515 Research Drive, Suite 30
Knoxville, TN, 37932
(865) 974-8001
Nonprofit college or university
Abstract
Human breath contains a treasure-trove of metabolic data, which has the potential to provide real time information representing an individual's baseline health status or rapidly categorize baseline deviations related to environmental stressors, including, biological or chemical agents, physical, heat and cold stress, sleep deprivation, pollutant or allergen exposure, and disease. The most prevalent and discriminating group of biomarkers in breath are the lipid regulatory molecules. We propose to quantitatively assess individual soldier operational readiness with a non-invasive, rapid, analysis of regulatory lipids in expired breath condensate. Proof-of-principal experiments, supported by DARPA, have demonstrated that regulatory lipid biomarkers (eicosanoids and platelet activation factors) are expressed in the breath condensate of mice, rats and piglets exposed to various toxins and pathogens. The biomarker data was reproducible and correlated to presymptomatic inductions of cytokines and host response proteins; both key indicators of immune system activation. Moreover, the data indicate that the pattern of lipid regulator molecules expressed were unique for each stressor. Phase I will test thirty subjects to demonstrate: 1) reproducibility of recovery, 2) individual and group baseline responses while at metabolic rest, physically stressed (aerobic exercise), and sleep deprived 3) profile discriminatory patterns representing the various stressed and unstressed states.

* information listed above is at the time of submission.

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