CHEMOPREVENTIVE AGENTS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4807
Agency Tracking Number:
4807
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
5221 River Road, Bethesda, MD, 20816
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
RONALD RAINERI
PRINCIPAL INVESTIGATOR
(301) 654-3400
Business Contact:
() -
Research Institution:
n/a
Abstract
THE OVERALL GOAL OF THIS STUDY IS THE DEVELOPMENT OF TWO IN VITRO TRANSFORMATION ASSAYS FOR THE EVALUATION OF CHEMO- PREVENTIVE AGENTS. THE TWO SYSTEMS UTILIZE PRIMARY SYRIAN HAMSTER EMBRYO CELLS AND RETROVIRAL-INFECTED FISCHER RAT EMBRYO CELLS (A CONTINUOUS CELL CULTURE). BOTH CELL TYPES ARE ROUTINELY TRANSFORMED BY CARCINOGENIC CHEMICALS WITH THEANCHORAGE-INDEPENDENT GROWTH ENDPOINT ASSOCIATED WITH TUMORIGENICITY. MODEL CHEMOPREVENTIVE AGENTS (INHIBITORS OFPROSTAGLANDIN SYNTHESIS AND PROTEASE INHIBITORS) WILL BE USED TO INHIBIT TRANSFORMATION BY CHEMICAL CARCINOGENS. CONDITIONS FOR MAXIMUM EFFECTIVENESS OF THE SELECTED CHEMO- PREVENTIVE AGENTS WILL BE ESTABLISHED DURING THIS PHASE I PROJECT. DURING PHASE II, THE USE OF FLUORESCENT ANTIBODIESTO ONCOGENE PRODUCTS WILL BE INVESTIGATED AS A MEANS OF DETECTING THE EMERGENCE OF MALIGNANT CELLS EARLIER THAN IS SEEN BY COLONY FORMATION IN SOFT AGAROSE. THIS WILL ALLOW MORE EFFECTIVE MEANS OF EVALUATING CHEMOPREVENTIVE AGENTS.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government