System for multidimensional analysis of growth and migration of neurons and neuro

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$195,343.00
Award Year:
2009
Program:
SBIR
Phase:
Phase I
Contract:
1R43MH085337-01
Award Id:
94014
Agency Tracking Number:
MH085337
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
MICROBRIGHTFIELD, INC., 185 ALLEN BROOK LN, STE 201, WILLISTON, VT, 05495
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
787008242
Principal Investigator:
JACOB GLASER
(802) 288-9290
JGLASER@MICROBRIGHTFIELD.COM
Business Contact:
SUSAN HENDRICKS
() -
susan@microbrightfield.com
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): We propose the Orion workstation, an innovative, next generation microscope system that provides analysis tools for fully-automated quantitative change analysis in neurite outgrowth dynamics and neuronal precursor migra tion. The algorithms that will form the basis of this software provide information about changes seen in individual neurites and cells, yielding results that summarize observed changes. The results will go beyond summary quantifications of all neuronal str uctures at each time point, however, because analysis tools are used to match individual objects between adjacent images thereby increasing inter-study reliability and reproducibility of time-lapse experiments. The proposed Orion workstation will enable so phisticated and detailed analysis of the dynamics of neurite outgrowth (i.e., as they change over time) in dissociated cell cultures in vitro and migration of neuronal precursors in slic cultures in situ compared to currently available technology. PUBLIC H EALTH RELEVANCE: The proposed Orion workstation will open new horizons in basic neuroscience as well as in neurotoxicology and pharmacological research and development, by providing a powerful and efficient multi-dimensional process to detect and analyze n eurite outgrowth and migration of neuronal precursors. The overall effect of this project will permit the collection of highly relevant, multifaceted data describing multiple cells within a culture system in an economical, systematic manner.

* information listed above is at the time of submission.

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