3D Virtual Slide System for Creation and Analysis of Focusable Digital Slides

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$362,544.00
Award Year:
2007
Program:
SBIR
Phase:
Phase II
Contract:
2R44MH076188-02A1
Agency Tracking Number:
MH076188
Solicitation Year:
2007
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
MICROBRIGHTFIELD, INC.
MICROBRIGHTFIELD, INC., 185 ALLEN BROOK LN, STE 201, WILLISTON, VT, 05495
Hubzone Owned:
Y
Socially and Economically Disadvantaged:
Y
Woman Owned:
Y
Duns:
787008242
Principal Investigator:
JACOB GLASER
(802) 288-9290
JGLASER@MICROBRIGHTFIELD.COM
Business Contact:
SUSAN HENDRICKS
(802) 288-9290
shendricks@mbfbioscience.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): Rigorous quantification methods of histological specimens have become a keystone in modern neuroscience such as investigations of neurogenesis, stem cell research, neurotransplantation, neurotoxicology, and the pathogenesis of neurodegenerative and neuropsychiatric diseases. Methods in current practice are not conducive to high-throughput studies because they are often manual and laborious to perform. There is a noticeable lack of computerized automated 3D quantitative histological analysis tools which can operate on large 3D image volumes. Furthermore, the widespread use of fluorescently labeled tissue sections imposes other limitations, particularly fading of fluorescent dyes, limited availability and tremendous costs of high-end confocal microscopes. We propose to develop a commercial system (Biolucida") to overcome this unsatisfactory situation. The core of Biolucida will be 3D virtual slides, which are digital representations (in X, Y and Z) of tissue specimens imaged through a microscope at the highest optical resolution. We will develop software for the acquisition, automated quantitative histological analysis, viewing, sharing and archiving of 3D virtual slides. As such, the use of Biolucida will fully surmount the aforementioned limitations. Consequently we expect that the launch of Biolucida will revolutionize the quantitative analysis of fluorescently labeled tissue sections in modern neuroscience.

* information listed above is at the time of submission.

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