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Novel Extracorporeal Therapy for the Reversal of Septic Shock and Restoring Hemodynamic Stability

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43GM144973-01
Agency Tracking Number: R43GM144973
Amount: $288,335.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: 300
Solicitation Number: PA20-272
Timeline
Solicitation Year: 2020
Award Year: 2022
Award Start Date (Proposal Award Date): 2022-09-01
Award End Date (Contract End Date): 2023-04-30
Small Business Information
305 College Road East
Princeton, NJ 08540
United States
DUNS: 830014077
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 PHILLIP CHAN
 (732) 329-8885
 pchan@cytosorbents.com
Business Contact
 RICHARD MCKAY
Phone: (732) 482-9991
Email: rmckay@cytosorbents.com
Research Institution
N/A
Abstract

PROJECT SUMMARY
The funds from this administrative supplement will be utilized for Technical and Business
Assistance (TABA). Specifically, we intend to use the funds to cover intellectual property
strategy consultation fees to provide us with a sound patent strategy for our novel polymer
sorbent LPSorb.
Sepsis is an extreme reaction to pathogen infection and is one of the deadliest conditions in the
world. The field of sepsis care currently lacks an effective treatment to counteract both the
bacterial-derived endotoxins found in certain types of sepsis and the massive cytokine-mediated
immune response to the infection that can lead to organ failure and death.
LPSorb has demonstrated the potential to be an extremely effective extracorporeal endotoxin
adsorber. When coupled with our cytokine adsorber CytoSorb, which is currently on the market,
LPSorb should provide a novel and effective therapy for deadly Gram-negative sepsis.
The innovative formulation developed by our polymer chemistry team will require intellectual
property protection to allow for continued innovation and to provide maximum revenue, enabling
the establishment of a viable new product line for the company.
To achieve this, we propose to use these supplemental funds to engage our longtime IP
counsel BakerHostetler to seek intellectual property counsel to develop a suitable patent
strategy which will ultimately enable us to efficiently pursue both material and application
patents for this innovative product.

* Information listed above is at the time of submission. *

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