Microdrop Dye Dispenser for Surgical Lasers

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 GM50602-1,
Agency Tracking Number: 25091
Amount: $81,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1994
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
1104 Summit Avenue, Suite 110, Plano, TX, 75074
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 David Wallace
 (214) 578-8076
Business Contact
Phone: () -
Research Institution
N/A
Abstract
This grant concerns the development of a superior laser surgical tool. We have found that laserablation is enhanced when tissue are pretreated with microdrops of dye, nominally 50um in diameter.The use of dye to couple the laser energy to the tissue has two advantages: (i) energy absorption isgoverned by the optical characteristics of the dye (not the tissue), thus the new-generation of cheap,compact diode laser can be harnessed to surgical task; (ii)because surgeons can "paint" the tissue withbrief burst of dye prior to each laser shot, they gain a new dimension of interactive control over theirlaser's impact on tissue. Our instrument combines a miniature, solid-state fluid microdispenser, basedon ink jet printing technology, and a laser fiber in a slim, endoscopic instrument. In Phase I of theresearch we will (i) evaluate various dyes, including lipophilic, "sticky" dyes for surgical use, (ii) explorehow the fundamentals of laser-tissue interaction (thermal diffusion, photoacoustic effects) are modifiedb use of dyes and (iii) assess the clinical efficacy (ablation efficiency vrs tissue damage) of selectedlaser-dye combinations. In Phase II we anticipate assembly of prototype instruments and pre-clinical,in vivo testing.

* Information listed above is at the time of submission. *

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