Ink-Jet Printed Nerve Conduits

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 2R44NS040625-02
Agency Tracking Number: NS040625
Amount: $0.00
Phase: Phase I
Program: SBIR
Awards Year: 2003
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (972) 578-8076
Business Contact
Phone: (972) 578-8076
Research Institution
DESCRIPTION (provided by applicant): Paralysis and loss of nerve function through trauma highlight the need for implantable device capable of restoring nerve function, without increasing tissue damage by requiring autologous nerve grafts. This study focuses on enhancing nerve regeneration in two ways First, fabrication precision and control for nerve guidance conduits will be increased This will result in nerve conduits that bioabsorb in eight weeks, resist in vivo compression through printed external support structures, and have uniform porosity Second, an NGF gradient within the conduit will be created by using high-precision ink jets NGF-enriched polymer will be deposited into a digitally controlled pattern. Achievement of the aims of this project will result in fabrication of nerve guidance conduits with the above-mentioned features and verification of nerve regeneration in animal models. The research plan will be carried out at three institutions MicroFab, University of Texas, Austin, and University of California, Irvine. Nerve conduits will be modeled, designed, fabricated and tested at MicroFab, they will be further characterized and in vitro studies will be carried out at University of Texas, and in vivo experiments, Walking-Track analysis, and electrophysiological studies will be carried out at University of California, Irvine. Proven cooperation among these three groups will insure project success.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government