EXPRESSION OF FOREIGN GENES IN WHOLE INSECTS USING RECOMBINANT BACULOVIRUS

Award Information
Agency:
Department of Agriculture
Branch
n/a
Amount:
$210,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
4647
Agency Tracking Number:
4647
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
400 Frontage Rd, West Haven, CT, 06516
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
DR. MARK A. COCHRAN
() -
Research Institution:
n/a
Abstract
BACULOVIRUSES HAVE GREAT POTENTIAL AS INSECT CONTROL AGENTS BY THEIR INHERENT SELECTIVITY AND SAFETY. RECOMBINANT BACUL OVIRUSES EXPRESSING FOREIGN GENES ENCODING FOR INSECTICIDAL PROTEINS SHOULD BE CONSIDERABLY MORE EFFECTIVE BIOLOGICAL CONTROL AGENTS THAN WILD-TYPE VIRUSES IN BOTH FIELD EFFICACYAND HOST RANGE. THE AIM OF THE PROPOSED RESEARCHIS TO INVESTINGATE THE BIOLOGY AND EFFECTS OR RECOMBINANT VIRUSES IN WHOLE INSECTS. AN EASILY ASSAYABLE GENE (B-GALACTOSIDASE), SEVERAL ACMNPV RECOMBINANTS, AND SUBCEPTIBLE LEPIDOPTERAN LARVAE WILL BE USED A MODEL MATERIALS. SUCH QUESTIONS AS THE TIME COURSE, SITE AND QUANTITY OF GENE EXPRESSION AND THE STABILITY OF VIRUS RECOMBINANTS FOLLOWING REPEATED PASSAGES, WILL BE ANSWERED.

* information listed above is at the time of submission.

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