EXPRESSION OF FOREIGN GENES IN WHOLE INSECTS USING RECOMBINANT BACULOVIRUS

Award Information
Agency: Department of Agriculture
Branch: N/A
Contract: N/A
Agency Tracking Number: 4647
Amount: $210,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1987
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Microgenesys, Inc.
400 Frontage Rd, West Haven, CT, 06516
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 () -
Business Contact
 DR. MARK A. COCHRAN
Phone: () -
Research Institution
N/A
Abstract
BACULOVIRUSES HAVE GREAT POTENTIAL AS INSECT CONTROL AGENTS BY THEIR INHERENT SELECTIVITY AND SAFETY. RECOMBINANT BACUL OVIRUSES EXPRESSING FOREIGN GENES ENCODING FOR INSECTICIDAL PROTEINS SHOULD BE CONSIDERABLY MORE EFFECTIVE BIOLOGICAL CONTROL AGENTS THAN WILD-TYPE VIRUSES IN BOTH FIELD EFFICACYAND HOST RANGE. THE AIM OF THE PROPOSED RESEARCHIS TO INVESTINGATE THE BIOLOGY AND EFFECTS OR RECOMBINANT VIRUSES IN WHOLE INSECTS. AN EASILY ASSAYABLE GENE (B-GALACTOSIDASE), SEVERAL ACMNPV RECOMBINANTS, AND SUBCEPTIBLE LEPIDOPTERAN LARVAE WILL BE USED A MODEL MATERIALS. SUCH QUESTIONS AS THE TIME COURSE, SITE AND QUANTITY OF GENE EXPRESSION AND THE STABILITY OF VIRUS RECOMBINANTS FOLLOWING REPEATED PASSAGES, WILL BE ANSWERED.

* information listed above is at the time of submission.

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government