Method for Isolation and Microassay of Lipoprotein (A)

Award Information
Agency:
Department of Health and Human Services
Amount:
$592,416.00
Program:
SBIR
Contract:
1 R43 HL55111-01,
Solitcitation Year:
N/A
Solicitation Number:
N/A
Branch:
N/A
Award Year:
1997
Phase:
Phase II
Agency Tracking Number:
29570
Solicitation Topic Code:
N/A
Small Business Information
Micronix
6856 Hawthorne Park Drive, Indianapolis, IN, 46220
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
N/A
Principal Investigator
 Mary Gaunt Kloepfer
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
Lipoprotein(a) [Lp(a)] has been labelled the most atherogenic lipoprotein in man. Current laboratorLp(a) employ immuno-quantitation of its apolipoprotein [apo(a)]. Because these methods are hamperedto plasminogen, apo(a) isoform dependence, antibody heterogeneity, and lack of standardization, noneapproved. One third of Lp(a)'s mass is cholesterol, and only one tenth is apo(a). We will develop olaboratory, and a semi-quantitative screening method for Lp(a) cholesterol [Lp(a)-C]. The methods exhigh content of carbohydrate, e.g. sialic acid. Lp(a) is separated from other lipoproteins by bindincarbohydrate structures to a specific solid-supported lectin, and analyzed by highly sensitive enzym

* information listed above is at the time of submission.

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