Method for Isolation and Microassay of Lipoprotein (A)

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$592,416.00
Award Year:
1997
Program:
SBIR
Phase:
Phase II
Contract:
1 R43 HL55111-01,
Award Id:
29570
Agency Tracking Number:
29570
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
6856 Hawthorne Park Drive, Indianapolis, IN, 46220
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Mary Gaunt Kloepfer
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
Lipoprotein(a) [Lp(a)] has been labelled the most atherogenic lipoprotein in man. Current laboratorLp(a) employ immuno-quantitation of its apolipoprotein [apo(a)]. Because these methods are hamperedto plasminogen, apo(a) isoform dependence, antibody heterogeneity, and lack of standardization, noneapproved. One third of Lp(a)'s mass is cholesterol, and only one tenth is apo(a). We will develop olaboratory, and a semi-quantitative screening method for Lp(a) cholesterol [Lp(a)-C]. The methods exhigh content of carbohydrate, e.g. sialic acid. Lp(a) is separated from other lipoproteins by bindincarbohydrate structures to a specific solid-supported lectin, and analyzed by highly sensitive enzym

* information listed above is at the time of submission.

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