Method for Isolation and Microassay of Lipoprotein (A)
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Mary Gaunt Kloepfer
AbstractLipoprotein(a) [Lp(a)] has been labelled the most atherogenic lipoprotein in man. Current laboratorLp(a) employ immuno-quantitation of its apolipoprotein [apo(a)]. Because these methods are hamperedto plasminogen, apo(a) isoform dependence, antibody heterogeneity, and lack of standardization, noneapproved. One third of Lp(a)'s mass is cholesterol, and only one tenth is apo(a). We will develop olaboratory, and a semi-quantitative screening method for Lp(a) cholesterol [Lp(a)-C]. The methods exhigh content of carbohydrate, e.g. sialic acid. Lp(a) is separated from other lipoproteins by bindincarbohydrate structures to a specific solid-supported lectin, and analyzed by highly sensitive enzym
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