DNA PROBES TO DETECT HUMAN PAPILLOMAVIRUS IN ORAL CANCER

Award Information
Agency:
Department of Health and Human Services
Branch:
N/A
Amount:
$500,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase II
Contract:
N/A
Agency Tracking Number:
7154
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Microprobe Corp.
1725 220th St Southeast #104, Bothell, WA, 98021
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
N/A
Principal Investigator
 Dennis E Schwartz Phd
 (206) 485-8566
Business Contact
Phone: () -
Research Institution
N/A
Abstract
IN SITU DNA-PROBE HYBRIDIZATION ASSAYS WILL BE USED TO DETERMINE THE TYPES OF HUMAN PAPILLOMAVIRUS (HPV) ASSOCIATEDWITH ORAL CANCERS. SHORT, SYNTHETIC DNA PROBES, SPECIFIC FOR HPV TYPES 6, 11, 16, 18, AND 31, WILL BE TESTED ON THIN SECTIONS OF TUMOR SPECIMENS FROM THE ARCHIVES OF THE DIVISION OF ORAL PATHOLOGY, UNIVERSITY OF WASHINGTON. THE SPECIMENS WILL INCLUDE PAPILLOMAS AND FRANK CARCINOMAS. THIS STUDY WILL DEMONSTRATE THE FEASIBILITY OF ROUTINE TESTING OF ORAL BIOPSIES FOR HPV INFECTION BY IN SITU HYBRIDIZATION AND MAY PROVIDE NEW INFORMATION REGARDING THE SPECIFIC TYPES OF HPV ASSOCIATED WITH ORAL MALIGNANCY. IN ADDITION, THIS STUDY WILL DIRECTLY COMPARE THE EFFICACY OF LONG, CLONED DNA PROBES AND SHORT, SYNTHETIC DNA PROBES IN IN SITU DNA HYBRIDIZATIONS. THE RESULTS OF THIS PROJECT WILL BE IMPORTANT FOR THE COMMERCIAL DEVELOPMENT OF NONISOTOPIC. DNA PROBE-BASED DIAGNOSTIC SYSTEMS FOR USE IN CLINICAL AND ORAL PATHOLOGY LABORATORIES.

* information listed above is at the time of submission.

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