THIS ORGANIZATION WILL REFINE, BUILD, AND COMMERCIALIZE A CONTROLLED ATMOSPHERE CHAMBER WHICH, WHEN OPERATED IN CONJUNCTION WITH A SCANNING ELECTRON MICROSCOPE (SEM), WILL ALLOW THE USER SIMULTANEOUSLY TO IMAGE AND PERFORM X-RAY ELEMENTAL ANALYSIS ON

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$41,789.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
3199
Agency Tracking Number:
3199
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
P.o. Box 5115, North Branch, NJ, 08876
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
JACK R. ALONZO
PRINCIPAL INVESTIGATOR
(201) 526-9192
Business Contact:
() -
Research Institution:
n/a
Abstract
THIS ORGANIZATION WILL REFINE, BUILD, AND COMMERCIALIZE A CONTROLLED ATMOSPHERE CHAMBER WHICH, WHEN OPERATED IN CONJUNCTION WITH A SCANNING ELECTRON MICROSCOPE (SEM), WILL ALLOW THE USER SIMULTANEOUSLY TO IMAGE AND PERFORM X-RAY ELEMENTAL ANALYSIS ON LIVING ORGANISMS. THE ACTUAL OPERATION OF A DIFFERENTIALLY PUMPED CHAMBER HAS PREVIOUSLY BEEN DEMONSTRATED WITH A TRANSMISSION ELECTRON MICROSCOPE (TEM). HOWEVER, VERY LITTLE RESEARCH HAS BEEN PERFORMED IN DEVELOPING A CHAMBER FOR THE SEM. THIS IS MAINLY DUE TO THE FACT THAT VERY FEW RESEARCHERS HAVE THE EQUIPMENT TO PERFORM SUCH STUDIES. WITH OUR PRESENT EQUIPMENT WE CAN DEVELOP A STATE-OF-THE-ART ENVIRONMENTAL CHAMBER. THIS CHAMBER COULD THEN ADVANCE ALL THE FIELDS OF BIOLOGY BY ALLOWING DYNAMIC STUDIES OF CELL-CELL INTERACTIONS AND CELL-CHEMICAL INTERACTIONS. VIDEO RECORDING OF THESE EVENTS WILL ALLOW DETAILED ANALYSIS OF THE INTERACTIONS. PHASE I FUNDING WILL ALLOW US TO MODIFY OUR CURRENTLY OPERATIONAL GAS REACTION STAGE INTO A PROTOTYPE ENVIRONMENTAL CHAMBER. THIS PROTOTYPE WILL BE USED TO DETERMINE THE OPTIMUM DIMENSIONS FOR TWO COAXIALLY ALIGNED APERTURES. THESE APERTURES WILL ALLOW PRESSURES APPROACHING 1 ATMOSPHERE TO EXIST AROUND THE SPECIMEN. THIS PROTOTYPE WILL ALSO PERMIT US TO DETERMINE EXPERIMENTALLY THE SIZE AND SHAPE OF A SCINTILLATOR-PHOTOMULTIPLIER TYPE DETECTOR THAT WILL YIELD THE MAXIMUM SIGNAL DETECTION. PHASE II FUNDING WILL ALLOW THE CONSTRUCTION OF THE STAGE AND INITIATION OF EXPERIMENTS ON LIVING ORGANISMS. AN AMERICAN MICROSCOPE MANUFACTURER HAS ALREADY EXPRESSED

* information listed above is at the time of submission.

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