SBIR Phase II: Membrane Protein Microarrays

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 0450262
Agency Tracking Number: 0318938
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2003
Solitcitation Year: N/A
Solitcitation Topic Code: N/A
Solitcitation Number: N/A
Small Business Information
MSI (Microsurfaces Inc)
4001 Stinson Blvd., Minneapolis, MN, 55421
Duns: N/A
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Athena Guo
 Dr
 (612) 789-0104
 athena@memsurface.com
Business Contact
 Athena Guo
Title: Dr
Phone: (612) 789-0104
Email: athena@memsurface.com
Research Institution
N/A
Abstract
This Small Business Innovation Research (SBIR) Phase II project proposes to develop a product platform based on polymer cushion coated glass slides with controlled surface charge density for membrane protein microarray fabrication. The key technical objectives for Phase II research are : (a) to complete quantitative studies on surface charge density in the formation of supported phospholipid bilayer (SPB) from charged lipids , (b) to develop the chemistry for the grafting / adsorption of polymer cushions, (c) to measure the activities of membrane proteins in SPBs, and (d) to fabricate membrane protein microarrays based on surface pre-patterning using soft lithography techniques. The commercial application of this project will be in the area of protein microarrays for use in disease diagnostics and for drug discovery research. The proposed technology will enable development of therapeutics aimed at membrane protein targets.

* information listed above is at the time of submission.

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