SBIR Phase II: Membrane Protein Microarrays

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$500,000.00
Award Year:
2005
Program:
SBIR
Phase:
Phase II
Contract:
0450262
Award Id:
63408
Agency Tracking Number:
0318938
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
4001 Stinson Blvd., Minneapolis, MN, 55421
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
AthenaGuo
Dr
(612) 789-0104
athena@memsurface.com
Business Contact:
AthenaGuo
Dr
(612) 789-0104
athena@memsurface.com
Research Institute:
n/a
Abstract
This Small Business Innovation Research (SBIR) Phase II project proposes to develop a product platform based on polymer cushion coated glass slides with controlled surface charge density for membrane protein microarray fabrication. The key technical objectives for Phase II research are : (a) to complete quantitative studies on surface charge density in the formation of supported phospholipid bilayer (SPB) from charged lipids , (b) to develop the chemistry for the grafting / adsorption of polymer cushions, (c) to measure the activities of membrane proteins in SPBs, and (d) to fabricate membrane protein microarrays based on surface pre-patterning using soft lithography techniques. The commercial application of this project will be in the area of protein microarrays for use in disease diagnostics and for drug discovery research. The proposed technology will enable development of therapeutics aimed at membrane protein targets.

* information listed above is at the time of submission.

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