BIOMIMETIC HYDROXYLATION OF SILICONE MEMBRANE SURFACES

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 8019
Amount: $46,167.00
Phase: Phase I
Program: SBIR
Awards Year: 1988
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Midmid Inc
University Research Ste 110, 419 Wakara Way, Salt Lake City, UT, 84108
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
CATALYTIC METALLOPORPHYRIN CHEMISTRY WILL BE UTILIZED TO DEVELOP A CHEMICAL TREATMENT PROCESS FOR SILICONE MEMBRANE SURFACES. SPECIFICALLY, THIS PROCESS (A) WILL SELECTIVELY HYDROXYLATE METHYL GROUPS ON DIMETHYLSILOXANE OLIGOMERS AND POLYMERS AT AMBIENT TEMPERATURE (B) WILL MINIMIZE ADDITIONALSURFACE CROSSLINKING AND CONTAMINATION, COMMON SIDE EFFECTS AND BYPRODUCTS OBSERVED IN PLASMA ETCHING OF SILICONES IN OXYGEN-CONTAINING ATMOSPHERES; (C) WILL PRODUCE SURFACES THAT CAN BE FURTHER DEVELOPED FOR COVALENT ATTACHMENT OF ANTITHROMBOGENIC COMPOUNDS. THE PROPOSED PHASE I R&D PROJECT WILL: (A) EVALUATE THE EFFICACY, SELECTIVITY, AND SPECIFICITY OF METALLOPORPHYRIN-CATALYZED OXIDATIONS OF SILICONE MATERIALS;(B) IDENTIFY EFFECTIVE REAGENTS AND OPTIMUM CONDITIONS FOR SURFACE CHEMICAL TREATMENTS AND DETERMINE THE NATURE AND DISTRIBUTION OF HYDROXYLATED SURFACE SITES; AND (3) EVALUATETHE EFFICIENCY OF THE CHEMICAL TREATMENT PROCESS ON SURFACESCOATED BY DIPPING AND PLASMA POLYMERIZATION TECHNIQUES.

* information listed above is at the time of submission.

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