Non-Invasive Instrument for Monitoring Changes in Intracranial Pressure

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43NS058065-01
Agency Tracking Number: NS058065
Amount: $182,029.00
Phase: Phase I
Program: SBIR
Awards Year: 2007
Solitcitation Year: 2007
Solitcitation Topic Code: N/A
Solitcitation Number: N/A
Small Business Information
MIMOSA ACOUSTICS
MIMOSA ACOUSTICS, 60 HAZELWOOD DR, STE 209, CHAMPAIGN, IL, 61820
Duns: 837418615
Hubzone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: Y
Principal Investigator
 PATRICIA JENG
 (217) 367-9740
 PSJ@AUDITORYMODELS.ORG
Business Contact
 PATRICIA JENG
Phone: (217) 367-9740
Email: psj@mimosaacoustics.com
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): A wide range of devastating brain injuries cause brain swelling or bleeding. Because the skull is fixed in volume, increases in the volume of its contents result in increases in intracranial pressure (ICP). Elevations of ICP can lead to worsening brain injury or death by compressing either blood vessels supplying the brain or vital brain structures themselves. Detecting and treating such increases in ICP is crucial to protecting the injured brain. Currently, the only methods to monitor ICP are invasive and require direct entry of a probe system through the skull. The major hypothesis of this proposal is that it is possible to monitor changes in intracranial pressure by non-invasive means using acoustic measurements. This method of measurement has significant advantages over current invasive measurements of monitoring ICP in that the measurements can be obtained conveniently and rapidly (in less than a minute) without invading the skull and with zero probability of infection. It is proposed to develop a practical instrument for monitoring changes in ICP using measurements of distortion product otoacoustic emissions (DPOAE) and middle ear impedance. Initial evaluation and refinement of the instrument will involve healthy normal hearing subjects on a tilt table. Subsequent evaluations will compare the instrument with the conventional invasive method of monitoring ICP with patients in the neurological intensive care unit of a major hospital. A wide range of devastating brain injuries cause brain swelling or bleeding. Because the skull is fixed in volume, increases in the volume of its contents result in increases in intracranial pressure (ICP). Elevations of ICP can lead to worsening brain injury or death by compressing either blood vessels supplying the brain or vital brain structures themselves. Detecting and treating such increases in ICP is crucial to protecting the injured brain. Currently, the only methods to monitor ICP are invasive and require direct entry of a probe system through the skull. The major hypothesis of this proposal is that it is possible to monitor changes in intracranial pressure by non-invasive means using acoustic measurements. This method of measurement has significant advantages over current invasive measurements of monitoring ICP in that the measurements can be obtained conveniently and rapidly (in less than a minute) without invading the skull and with zero probability of infection.

* information listed above is at the time of submission.

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