MAGNETIC MICROCLUSTER FOR MRI CONTRAST AGENTS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 18998
Amount: $49,999.00
Phase: Phase I
Program: SBIR
Awards Year: 1992
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Molecular Bioquest Inc
8 Commerce Drive, Atkinson, NH, 03811
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Mark S Chagnon
 (603) 893-0060
Business Contact
Phone: () -
Research Institution
N/A
Abstract
A NOVEL CLASS OF MATERIAL HAS BEEN DISCOVERED THAT EXHIBITS NON-MAGNETIC BEHAVIOR IN ITS NATIVE (SUB 50A) STATE, BUT WHEN ASSEMBLED INTO CLUSTERS OF ABOVE 500A IN DIAMETER EXHIBITS SUPERPARAMAGNETIC BEHAVIOR. MATERIALS OF THIS TYPE CAN BE PREPARED AS BIODEGRADABLE 500A CLUSTERS, INJECTED INTO PATIENTS AND USED AS SAFE, NON-TOXIC, DEGRADABLE MRI CONTRAST AGENTS. A RESEARCH PROGRAM WILL UTILIZE THESE MAGNETIC CLUSTERS AS AGENTS FOR MRI CONTRAST, TO BUILD CLUSTERS OF VARIOUS SIZES FOR SIZE EXCLUSION DELIVERY TO SPECIFIC ORGANS FOR CONTRASTING IN MRI AND TO STUDY THE 60 HZ AND RP MAGNETIC FIELD RESPONSE OF THESE CLUSTERS VS, CLUSTER SIZE, TIME, PH AND TEMPERATURE. WE ACKNOWLEDGE THE NEED FOR IN VIVO TESTING TO DETERMINE THE VIABILITY OF THIS RESEARCH, AND WHILE SUCH A PROGRAM IS NOT FEASIBLE WITHIN THE LIMITS OF AN SBIR PHASE I PROJECT, A BIOLOGICAL ANALYSIS OF CANDIDATE MATERIALS WILL BE CONDUCTED AND A STRATEGIC PLAN FOR ACCOMPLISHING IN VIVO TESTING IS IN PLACE. BASED UPON A SUCCESSFUL PHASE I, WE HAVE ALREADY ENTERED INTO RESEARCH COLLABORATION AGREEMENTS WITH SIGNIFICANT INTERNATIONAL PHARMACEUTICAL COMPANIES AND RESEARCH CENTERS THAT HAVE THE ABILITY AND INTENT TO CONDUCT IN VIVO TESTING IN ANIMALS. THESE CONFIDENTIAL RELATIONSHIPS WILL BE DISCLOSED WITHIN THE PROTECTED PORTION OF THIS PROPOSAL ONLY.

* information listed above is at the time of submission.

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