TOPICAL PRODRUGS FOR TREATMENT OF ACNE AND SKIN DISEASES

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$263,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
2956
Agency Tracking Number:
2956
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
P.o. Box 41777, Memphis, TN, 38174
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Harlie A. Parish
Principal Investigator
(901) 454-1919
Business Contact:
() -
Research Institution:
n/a
Abstract
THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DEVELOP A COMMERCIAL PRODUCT FOR THE TOPICAL TREATMENT OF ACNE AND SKIN DISEASES. THE SPECIFIC AIM OF THE PROPOSAL IS TO INVENT A PRODRUG THAT CAN BE USED EFFECTIVELY AND SAFELY FOR THE TOPICAL TREATMENT OF ACNE. SINCE ISOTRETINOIN (13-CIS-RETINOIC ACID, ACCUTANE-ROCHE) ADMINISTERED ORALLY CAUSES BIRTH DEFECTS AND APPLIED TOPICALLY IS IRRITATING, WE HAVE DESIGNED PRODRUGS OF ISOTRETINOIN. THESE PRODRUGS ARE INTENDED 1.TO BE APPLIED TOPICALLY, 2.TO MAKE ISOTRETINOIN BIOAVAILABLE AT THE TARGET SITE BY HYDROLYSIS OF THE PRODRUG IN THE SKIN, AND THREE PRODRUGS HAVE ALREADY BEEN SYNTHESIZED AND TESTED IN THE TOPICAL RHINO MOUSE ASSAY AND THE ORAL HAMSTER SEBACEOUS GLAND ASSAY. ONE OF OUR COMPOUNDS, MDI 3831101, IS AS EFFECTIVE AS ISOTRETINOIN IN THE SAME ASSAYS. SINCE THIS IS A NEW COMPOUND, A PATENT APPLICATION HAS BEEN FILED.WE PROPOSE TO SYNTHESIZE ADDITIONAL SAMPLES OF MDI 3831101 AND ADDITIONAL PRODRUGS OF ISOTRETINOIN IN ORDER TO OPTIMIZE OUR LEAD COMPOUND.

* information listed above is at the time of submission.

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