TOPICAL PRODRUGS FOR THE TREATMENT OF PSORIASIS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1991
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
7907
Agency Tracking Number:
7907
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Box 41777, Memphis, TN, 38174
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
PSORIASIS IS A DISEASE THAT AFFECTS MILLIONS OF AMERICANS WITH CHRONIC RECURRENT EXACERBATIONS AND REMISSIONS THAT AREEMOTIONALLY AND PHYSICALLY DEBILITATING. SEVERAL TREATMENTSARE AVAILABLE, BUT IN MANY CASES THESE ARE INADEQUATE. THIS APPLICATION IS BASED ON THE PREMISE THAT TOPICAL ADMINISTRATION OF PRODRUGS SHOULD RESULT IN HIGH CONCENTRATIONS OF THE ACTIVE DRUG AT THE LESION SITE WITH LOWER CONCENTRATIONS SYSTEMICALLY. LESS TOTAL DOSE COULD BE USED THAN WITH ORAL ADMINISTRATION. THE EFFICACY OF THE DRUG MIGHT BE MAINTAINED AT THIS LOWER DOSE; THUS, TOPICAL PRODRUGS MIGHT LEAD TO SAFER PRODUCTS. WE PROPOSE TO DESIGN, SYNTHESIZE AND TEST TOPICAL PRODRUGS OF SOME OF THE EFFECTIVE SYSTEMIC DRUGS FOR PSORIASIS, PLUS SOME COMPOUNDS WHOSE POTENTIAL EFFICACY IS PREDICTED FROM A BIOCHEMICAL UNDERSTANDING OF PSORIASIS. THERE IS A SUBSTANTIAL VOLUME OF LITERATURE ON THE PATHOPHYSIOLOGY OF PSORIASIS AND THE THERAPEUTIC POTENTIAL OF LIPOXYGENASE INHIBITORS. SINCE THERE IS NO ANIMAL MODEL FOR PSORIASIS, THE BIOLOGICALTESTING WILL BE DONE WITH THE ARACHIDONIC ACID MOUSE EAR MODEL DESIGNED TO TEST LIPOXYGENASE INHIBITORS. IF THIS PHASE I PROJECT IS SUCCESSFUL, PHARMACOLOGICAL, TOXICOLOGICAL, AND CLINICAL STUDIES WILL BE PROPOSED FOR PROMISING CANDIDATE PRODRUGS.

* information listed above is at the time of submission.

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