Alpha Adrenergic Agonists for CPR

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 HL51716-1,
Agency Tracking Number: 25146
Amount: $72,595.00
Phase: Phase I
Program: SBIR
Awards Year: 1994
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Molecular Design
9 Tishomingo Cove, Memphis, TN, 38111
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 William Purcell
 (901) 528-6050
Business Contact
Phone: () -
Research Institution
N/A
Abstract
In the United States alone, approximately 450,000 people yearly suffer a cardiac arrest outsidethe hospital. Less than 10% of these patients are discharged from the hospital alive, and of these,approximately 60% suffer some form of permanent neurologic injury. The poor resuscitation rates andneurologic outcome result in part from the low level of myocardial and cerebral blood flow and oxygendelivery generated during cardiopulmonary resuscitation (CPR). While epinephrine (an alpha 1,2;beta-1,2 adrenergic agonist) is currently used during CPR to enhance perfusion, it is unclear whatspecific adrenergic agonist components are required to optimize hemodynamics and minimize toxicity(i.e. increases on oxygen consumption and ventricular dysrhythmias) in this setting. Our specific aimis to synthesize adrenergic agonists that will maximally enhance myocardial and cerebral hemodynamics,resuscitation rates (without the development of hemodynamically significant ventricular dysrhythmias),and neurologic outcome following resuscitation from cardiac arrest.

* information listed above is at the time of submission.

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