DEVELOPMENT OF AN IMAGING MARKER FOR PARKINSON'S DISEASE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$99,755.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43NS043826-01
Award Id:
61141
Agency Tracking Number:
NS043826
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
MOLECULAR NEUROIMAGING, LLC, 60 TEMPLE ST, STE 8A, NEW HAVEN, CT, 06510
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DANNA JENNINGS
(203) 401-4300
DJENNINGS@MNIMAGING.COM
Business Contact:
JACK MARIOTTI
(203) 401-4300
JMARIOTTI@MNIMAGING.COM
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): The development of disease modifying agents in Parkinson's disease has rapidly expanded the need for in vivo markers for diagnosis and monitoring disease progression. Dopamine transporter (DAT) imaging offers the promise of an objective measure of dopaminergic degeneration allowing for identification of changes in the brain that occur early in the illness, prior to clinical diagnosis. The primary goal of this project is to examine the sensitivity and specificity of DAT imaging using (3-CIT and SPECT imaging as a diagnostic marker in subjects with suspected PD or PS. Neurologists will identify subjects in whom they have genuine uncertainty regarding diagnosis of PD or PS. The neurologists will be asked to document their 'best guess' diagnosis on a Diagnostic Accuracy Questionnaire at the time of referral. Subjects with suspected PD or PS will be evaluated clinically and with DAT imaging at MNI. The blinded Parkinson's expert will re-examine the subject in 6 months and make a final clinical diagnosis, which will serve as the gold standard diagnosis for each subject. The DAT imaging diagnosis will be compared to the 'gold standard' clinical diagnosis to determine the sensitivity of (3-CIT and SPECT imaging as a diagnostic marker in PD and PS. This project is a crucial step to begin to establish B-CIT and SPECT imaging as an objective diagnostic biomarker prior to definitive diagnosis.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government