In vivo evaluation of a new ligand with picomolar affinity for the serotonin tran

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
2008
Program:
SBIR
Phase:
Phase I
Contract:
1R43MH079568-01A1
Agency Tracking Number:
MH079568
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
MOLECULAR NEUROIMAGING, LLC
MOLECULAR NEUROIMAGING, LLC, 60 TEMPLE STREET, SUITE 8A, NEW HAVEN, CT, 06510
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
020285081
Principal Investigator:
GILLES TAMAGNAN
(203) 401-4309
GTAMAGNAN@INDD.ORG
Business Contact:
() -
jmariotti@indd.org
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): The goal of this research project is to validate in humans a new ligand with picomolar affinity for the serotonin transporter. It will permit quantitative measurement of serotonin transporter (5- HTT) sites in living br ain by imaging with single photon emission tomography (SPECT). The serotonin transporter is known to play a critical role in several physiological and pathophysiological processes, including depression, anxiety, seasonal affective disorder, bulimia, and ps ychosis, as demonstrated by post-mortem data, clinical efficacy of therapies affecting this target site, and imaging studies. A radiotracer that binds specifically to 5-HTT is of great utility in diagnosis, monitoring treatment, and research of these disor ders. There is a need for better tracers that allow quantitation in areas of the brain with low 5-HTT densities such as the cortex.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government