In vivo evaluation of a new ligand with picomolar affinity for the serotonin tran
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MOLECULAR NEUROIMAGING, LLC, 60 TEMPLE STREET, SUITE 8A, NEW HAVEN, CT, 06510
AbstractDESCRIPTION (provided by applicant): The goal of this research project is to validate in humans a new ligand with picomolar affinity for the serotonin transporter. It will permit quantitative measurement of serotonin transporter (5- HTT) sites in living br ain by imaging with single photon emission tomography (SPECT). The serotonin transporter is known to play a critical role in several physiological and pathophysiological processes, including depression, anxiety, seasonal affective disorder, bulimia, and ps ychosis, as demonstrated by post-mortem data, clinical efficacy of therapies affecting this target site, and imaging studies. A radiotracer that binds specifically to 5-HTT is of great utility in diagnosis, monitoring treatment, and research of these disor ders. There is a need for better tracers that allow quantitation in areas of the brain with low 5-HTT densities such as the cortex.
* information listed above is at the time of submission.