In vivo evaluation of a new ligand with picomolar affinity for the serotonin tran

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43MH079568-01A1
Agency Tracking Number: MH079568
Amount: $500,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2008
Solitcitation Year: 2008
Solitcitation Topic Code: N/A
Solitcitation Number: PHS2007-2
Small Business Information
MOLECULAR NEUROIMAGING, LLC
MOLECULAR NEUROIMAGING, LLC, 60 TEMPLE STREET, SUITE 8A, NEW HAVEN, CT, 06510
Duns: 020285081
Hubzone Owned: Y
Woman Owned: Y
Socially and Economically Disadvantaged: Y
Principal Investigator
 GILLES TAMAGNAN
 (203) 401-4309
 GTAMAGNAN@INDD.ORG
Business Contact
Phone: (203) 401-4351
Email: jmariotti@indd.org
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): The goal of this research project is to validate in humans a new ligand with picomolar affinity for the serotonin transporter. It will permit quantitative measurement of serotonin transporter (5- HTT) sites in living br ain by imaging with single photon emission tomography (SPECT). The serotonin transporter is known to play a critical role in several physiological and pathophysiological processes, including depression, anxiety, seasonal affective disorder, bulimia, and ps ychosis, as demonstrated by post-mortem data, clinical efficacy of therapies affecting this target site, and imaging studies. A radiotracer that binds specifically to 5-HTT is of great utility in diagnosis, monitoring treatment, and research of these disor ders. There is a need for better tracers that allow quantitation in areas of the brain with low 5-HTT densities such as the cortex.

* information listed above is at the time of submission.

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