DOMAIN-SPECIFIC ANTIBODIES TO HUMAN ERB-2/NEU PROTEIN

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$447,480.00
Award Year:
1990
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
11130
Agency Tracking Number:
11130
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
19 Firstfield Rd, Gaithersburg, MD, 20878
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
IN 20 TO 40 PERCENT OF HUMAN BREAST CANCERS, THE ERBB-2 OR NEU GENE IS AMPLIFIED, LEADING TO MRNA AND PROTEIN OVEREXPRESSION. THIS OVEREXPRESSION IS LIKELY TO BE INVOLVED IN EITHER THE INITIATION OR PROGRESSION OF THESE TUMOR CELLS. AMPLIFICATION OF THE ERBB-2 GENE HAS BEEN LINKED TO A POORER PROGNOSIS. IN PHASE I, MONOCLONAL AND POLYCLONAL ANTIBODIES TO EXTRACELLULAR AS WELL AS INTRACELLULAR REGIONS OF THE ERBB-2 PROTEIN WILL BE GENERATED. ANTIGEN WILL BE PREPARED FROM TWO SOURCES: MOUSE FIBROBLASTS EXPRESSING LARGE AMOUNTSOF THE HUMAN ERBB-2 PROTEIN AND BACTERIA GENETICALLY ENGINEERED TO EXPRESS SPECIFIC REGIONS OF THE ERBB-2 PROTEIN. THE RESULTING ANTIBODY PREPARATIONS WILL BE TESTEDFOR THEIR ABILITY TO SPECIFICALLY RECOGNIZE HUMAN ERBB-2 PROTEIN. IN PHASE II, THE USES OF THESE ANTIBODIES IN DIAGNOSIS AND THERAPY OF BREAST CANCER WILL BE EXPLORED.

* information listed above is at the time of submission.

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