SYNTHESIS AND BIOMEDICAL APPLICATIONS OF FLUORESCENT PROBES

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1989
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
4942
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Molecular Probes Inc.
4849 Pitchford Ave, Eugene, OR, 97402
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dr Richard P Haugland
Principal Investigator
(503) 998-6254
Business Contact:
() -
Research Institution:
n/a
Abstract
MOLECULAR PROBES AIMS TO DEVELOP SEVERAL NEW FLUORESCENT PROBES OF UTILITY IN MANY AREAS. FLUORESCENT DYES HAVE EXTENSIVE APPLICATIONS FOR DETERMINATION OF BIOMOLECULAR STRUCTURES AND MECHANISMS, CELL PROPERTIES AND INTERACTIONS,NORMAL AND DISEASE STATES, AND AS ULTRASENSITIVE VISIBLE TRACERS. NEW DYES ARE REQUIRED FOR GREATER SENSITIVITY AND SPECIFICITY OF DETECTION, IMPROVED SPECTRAL PROPERTIES, AND TO FACILITATE APPLICATIONS OF RECENT DEVELOPMENTS IN LOW- COST EXCITATION SOURCES. OTHER DYES ARE DESIGNED FOR LABELING SINGLE CELLS, CONTROLLED RELEASE OF DYES AND DRUGS INSIDE CELLS, AND SPECIFIC INVESTIGATIONS OF TUBULIN, ADRENERGIC RECEPTORS, AND AN ENZYME. THE NEW PROBES WILL BESYNTHESIZED AND CHARACTERIZED BY MOLECULAR PROBES, THEN EVALUATED FOR THEIR BIOCHEMICAL EFFECTIVENESS IN COLLABORA- TION WITH SEVERAL OUTSIDE RESEARCH GROUPS. AN ADVISORY COMMITTEE WILL BE FORMED TO SEEK FURTHER COLLABORATIONS ON DEVELOPMENT OF FLUORESCENCE APPLICATIONS AND TO GUIDE FUTURERESEARCH EFFORTS OF THE COMPANY.

* information listed above is at the time of submission.

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