DEVELOPMENT OF NEW LATEX-BASED FLUORESCENT REAGENTS

Award Information
Agency:
Department of Health and Human Services
Branch:
N/A
Amount:
$530,721.00
Award Year:
1994
Program:
SBIR
Phase:
Phase II
Contract:
N/A
Agency Tracking Number:
18955
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Molecular Probes Inc.
4849 Pitchford Avenue, Eugene, OR, 97402
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
N/A
Principal Investigator
 John M Brinkley
 (503) 344-3007
Business Contact
Phone: () -
Research Institution
N/A
Abstract
WE WILL DEVELOP APPLICATIONS IN BASIC AND APPLIED RESEARCH AND IN MEDICAL DIAGNOSTICS FOR THE FLUORESCENT LATEX MICROSPHERES THAT HAVE BEEN PREPARED. THE SUPERIORITY OF THESE PRODUCTS IN TERMS OF THEIR RANGE OF SIZE, WAVELENGTH AND FLUORESCENCE INTENSITY WILL ENHANCE THEIR APPLICATION IN AREAS OF RESEARCH AND INDUSTRY THAT HAVE SENSITIVITY REQUIREMENTS THAT CURRENTLYAVAILABLE FLUORESCENT LATEX AND OTHER FLUORESCENT REAGENTS CANNOT MEET. THE NEW MICROSPHERES WILL BE PREPARED FROM OIL-SOLUBLE FLUORESCENT DYES RECENTLY DEVELOPED BY OUR RESEARCH. THE SPECIFIC APPLICATIONS ARE: (1) NEW FLUORESCENT LATEX-BASED HYBRIDIZATION REAGENTS, (2) LABELINGREAGENTS WITH IMPROVED FLUORESCENCE INTENSITY, GREATER STOKES SHIFTS AND MULTIPLE EXCITATION/ EMISSION FOR BETTER DETECTABILITY AND MULTI-COLOR APPLICATIONS IN IMAGING AND FLOW CYTOMETRY, AND (3) NEW, ULTRA-SENSITIVE FLUORESCENT PROBES FOR LOW-DENSITY CELLULAR RECEPTORS.

* information listed above is at the time of submission.

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