Selection and Testing of Recombinant CAV 2- Rabies Vaccine for Oral Immunization of Wildlife

Award Information
Agency: Department of Agriculture
Branch: N/A
Contract: 2006-33610-16801
Agency Tracking Number: 2006-00528
Amount: $79,700.00
Phase: Phase I
Program: SBIR
Awards Year: 2006
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
882 S. Matlack Street Suite 105, West Chester, PA, 19382
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Jeffrey Mattis
 Sr. Vice President, Scientific Affairs
 (610) 738-7938
Business Contact
 Koon Pak
Title: President and CEO
Phone: (610) 738-7938
Research Institution
Extensive worldwide reservoirs of rabies virus (RV) in wildlife and stray dogs continue to pose a serious risk of lethal infection of humans and cause a high economic burden. Immunization of wildlife and stray dogs with live vaccines is the only effective method to control and eventually eliminate rabies in carnivore species worldwide. In this application we propose to select canine adenovirus type-2 (CAV2) clones that optimally express the rabies virus (RV) G protein from previously engineered replication-competent CAV 2 - RVG constructs. These selected CAV 2-RVG viruses will be evaluated for safety and efficacy in laboratory animals as an initial proof of concept.

* Information listed above is at the time of submission. *

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