SBIR Phase I: A Novel Resonant-Enhanced Crystallization Process

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: N/A
Agency Tracking Number: 0214760
Amount: $99,999.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 2002
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
1901 South Franklin, Butte, MT, 59701
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Fangxiao Yang
 (406) 723-2222
Business Contact
Phone: () -
Research Institution
This Small Business Innovation Research (SBIR) Phase I project proposes to develop a novel Resonant-Enhanced Crystallization (REC) Process. REC technology is similar to conventional impeller stirring crystallization but with enhanced mass and heat transfer, low shear or reduced crystal breakage, and improved crystal size distribution. Purification and separation by crystallization is a multicomponent mass transfer phenomenon of the crystallizing solute and impurity solutes. Mass and heat transfer in crystallization process are key factors affecting crystal growth rate, size distribution and habit. However, in conventional crystallizers, the mass transfer coefficient is maximized when crystals are in their terminal velocity and increased agitation results in significant crystal breakage. The proposed technology will further increase mass transfer even in cases where crystals are in suspended status. Due to the low shear associated with the acoustic agitation, crystal breakage will be minimal. The second nucleation will also be reduced and therefore, crystal size distribution will be improved. The objective of this proposed research is to incorporate low-frequency acoustic agitation to the crystallization process to greatly enhance mass and heat transfer. This is expected to improve crystal growth rate, size distribution and quality. The commercial applications of this project are in the area of pharmaceutical separation and purification.

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government