Transdermal Delivery of Anti-Malarial Drug

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-05-C-0050
Agency Tracking Number: A043-200-1213
Amount: $70,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2005
Solicitation Year: 2004
Solicitation Topic Code: A04-201
Solicitation Number: 2004.3
Small Business Information
1901 South Franklin, Butte, MT, 59701
DUNS: 836287680
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Fangxiao Yang
 Biochemical Engineer
 (406) 723-2222
Business Contact
 Lawrence Farrar
Title: President
Phone: (406) 723-2222
Research Institution
This Phase I proposal is aimed to develop a technology to delivery lipophilic therapeutic ingredients in broad and antimalarial drug primaquine in specific through skins. The proposed driving force of delivering target drugs is the opposite chemical affiliation of storage copolymer matrix and active therapeutic ingredient. The technology includes the formulation of patches - hydrophilic polymers, selection of permeation enhancers, encapsulation of primaquine in the polymers and drug diffusion flux measurements. The patches will be tested in vitro with cadaver skins for primaquine release or diffusion rate in the Phase I study. In Phase II study, the tests will apply to live animals and human subjects for delivery efficiency evaluation. The key features of the proposed transdermal delivery devices are: · Effective delivery lipophilic anti-malarial drug to the skin · Controllable dosage in the preparation · Enhanced compliance for administration of soldiers · Easy to be carried with soldier and long storage life · Easy and inexpensive to be prepared · Easy to be applied by users The proposed study meets the topic narrative for DOD solicitation A04-200 "Novel Routes of Drug Administration to Enhance Compliance in Soldiers"

* Information listed above is at the time of submission. *

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