PROSTATE CANCER CHIP

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43CA097844-01
Agency Tracking Number: CA097844
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2002
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
MOREWOOD MOLECULAR SCIENCES, INC, 5001 CENTRE AVE, PITTSBURGH, PA, 15213
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 HAICHING MA
 (610) 722-0247
 HAICHING@MOREWOODMOLECULAR.COM
Business Contact
 CHRISTOPHE SEVRAIN
Phone: (412) 697-2920
Email: CHRISTOPHE@MOREWOODMOLECULAR.COM
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): We seek to create an affordable and easily implemented proteomic tool in the form of a low cost "enzyme activity and immunodetection chip" for evaluation of enzyme activities and antigenic determinations at the level of 400 detections per cm2. Specific Aim 1 will focus on the validation and calibration of enzyme activity chemistries and antigen determination chemistries that are suited for reduction to a chip-based format at the 5 nanoliter scale per reaction. Specific Aim 2 will focus on the development of low cost microfluidics technology for activation of the enzyme/Immuno chips using minimal volumes of biological sample. We seek to conduct 400 detections using 10 to 100 microliters of biological fluid. Specific Aim 3 will focus on the scale down of the chemistries of Aim 1 to a chip based format where each reaction volume is 5 nanoliters and these reactions are activated with test fluids using the microfluidics technology developed in Aim 2. Preliminary studies have demonstrated the feasibility of activating thousands of individual 5 nanoliter reaction centers with a microliter of fluid sample. The Phase I activities will lead toward establishing chip chemistries and microfluidic technologies for a commercialized chip to aid in prostate cancer diagnostics.

* Information listed above is at the time of submission. *

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