PROSTATE CANCER CHIP

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43CA097844-01
Award Id:
60094
Agency Tracking Number:
CA097844
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
MOREWOOD MOLECULAR SCIENCES, INC, 5001 CENTRE AVE, PITTSBURGH, PA, 15213
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
HAICHINGMA
(610) 722-0247
HAICHING@MOREWOODMOLECULAR.COM
Business Contact:
CHRISTOPHESEVRAIN
(412) 697-2920
CHRISTOPHE@MOREWOODMOLECULAR.COM
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): We seek to create an affordable and easily implemented proteomic tool in the form of a low cost "enzyme activity and immunodetection chip" for evaluation of enzyme activities and antigenic determinations at the level of 400 detections per cm2. Specific Aim 1 will focus on the validation and calibration of enzyme activity chemistries and antigen determination chemistries that are suited for reduction to a chip-based format at the 5 nanoliter scale per reaction. Specific Aim 2 will focus on the development of low cost microfluidics technology for activation of the enzyme/Immuno chips using minimal volumes of biological sample. We seek to conduct 400 detections using 10 to 100 microliters of biological fluid. Specific Aim 3 will focus on the scale down of the chemistries of Aim 1 to a chip based format where each reaction volume is 5 nanoliters and these reactions are activated with test fluids using the microfluidics technology developed in Aim 2. Preliminary studies have demonstrated the feasibility of activating thousands of individual 5 nanoliter reaction centers with a microliter of fluid sample. The Phase I activities will lead toward establishing chip chemistries and microfluidic technologies for a commercialized chip to aid in prostate cancer diagnostics.

* information listed above is at the time of submission.

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