Development of MicroFluidic Palette for Cellular Responses to Chemical Stimuli

Award Information
Agency:
Department of Commerce
Branch
National Institute of Standards and Technology
Amount:
$90,000.00
Award Year:
2010
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
95254
Agency Tracking Number:
311-92-2010
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
5500 Nobel Drive, Madison, WI, 53711
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
119165251
Principal Investigator:
Elizabeth Vu
(608) 227-4521
Business Contact:
() -
Research Institution:
n/a
Abstract

Current research tools to understand tumor cell migration and metastases are limited to linear gradients or constant flow across cells skewing results. Researchers at the National Institute of Standards and Technology developed a tool called the microfluidic palette which exposes cells to chemical stimuli in a static environment overcoming the limitations above. Several improvements are necessary before this technology can be put to use in research. 1) Simplify the current complex assembly and connections, 2) decrease the excessively large footprint, 3) integrate temperature control to enable mammalian cell culture. We will demonstrate a device design engineered to simplify use and utilize space efficiently. The device will occupy and 1”x3” slide footprint containing reservoirs for reagents and waste, demonstrate robust control of temperature, dissolved gas concentration, generation of a non-linear gradient and, multi-day study of tumor cell chemotaxis. While this phase I project will focus on a specific application, the system will be designed in a modular fashion that supports a variety of palette designs with up to four different stimuli.

* information listed above is at the time of submission.

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