SBIR Phase II: Compact genetic assessment using the Infrarray SNAP (Simple Nucleic Acid Profiler)

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 0724423
Agency Tracking Number: 0611264
Amount: $499,986.00
Phase: Phase II
Program: SBIR
Awards Year: 2007
Solicitation Year: 2004
Solicitation Topic Code: BT
Solicitation Number: NSF 04-604
Small Business Information
Nanohmics, Inc
6201 East Oltorf St., Suite 100, Austin, TX, 78741
DUNS: 100651798
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Steve Savoy
 PhD
 (512) 389-9990
 ssavoy@nanohmics.com
Business Contact
 Steve Savoy
Title: PhD
Phone: (512) 389-9990
Email: ssavoy@nanohmics.com
Research Institution
N/A
Abstract
This Small Business Innovation Research (SBIR) Phase II research project aims to further develop a microfluidic device for the detection of nucleic acids for a variety of studies where genetic analysis and identification of target sequences are required. The instrument proposed is designed to be compact and capable of reading a disposable cartridge on which sample preparation, amplification, and multiplex detection, with a modest-sized microarray, are performed. The proposed instrument is enabled by direct imaging of a PhotoGenerated Reagent (PGR) microarray, with an image sensor positioned near the face of the microarray. It is also enabled by the use of up-converting phosphors as the label, which are in turn excited by infrared radiation that passes through the silicon microarray. The development of and inexpensive, fully integrated and automated microfluidic device for use in genetic analysis would give individuals in academic, commercial and defense settings access to affordable microarray analysis. The availability of such a versatile platform would allow the development of arrays for any nucleic acid target, as well as easy multiplexing. With such a platform, production of custom arrays and off-the-shelf ones will be achieved with great facility. Moreover, the integrated platform will reduce the cost and effort associated with microarray analysis.

* information listed above is at the time of submission.

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