Caged Metal Cluster and Colloid Immunoprobes

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$695,098.00
Award Year:
1996
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
22289
Agency Tracking Number:
22289
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
25 East Loop Road Suite 124, Stony Brook, NY, 11790
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Richard D. Powell
(516) 444-8815
Business Contact:
() -
Research Institution:
n/a
Abstract
New classes of immunolabels will be produced comprising large metal particles encapsulated within coordination shells of stabilizing ligands, the naturally occurring hollow protein apoferritin, or new synthetic inclusion molecules. The new probes will combine the high electron density, ease of visualization and range of sizes available with colloidal gold probes with the non-aggregation, high penetrating ability and sensitivities of smaller gold cluster immunoprobes. Methods are proposed for the chemically controlled growth of large bimetallic cluster complexes, colloids by catalytic metal deposition, ligand capping, and for the preparation of heavy atom cluster complexes and colloids within the hollow protein apoferritin. Syntheses are proposed for cage molecules with internal diameters from 5 nm to 20 nm, constructed using large gold cluster complexes, rigid rod supports and cross-linked flat plates. This unprecedented new class of large inclusion compounds with novel physical and chemical properties will be precursors to new imaging reagents, drug delivery systems and materials.

* information listed above is at the time of submission.

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