IMPROVED MRI CONTRAST AGENTS
Department of Health and Human Services
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Small Business Information
NANOPROBES, INC., 95 HORSEBLOCK RD, YAPHANK, NY, 11980
Socially and Economically Disadvantaged:
AbstractA new class of MRI contrast agents has been discovered and synthesized by Nanoprobes. Initial MRI animal studies showed excellent definition of some types of brain tumors, which were undetectable with the commonly used agent, gadodiamide. Furthermore, initial toxicity studies showed the agents to be non-toxic. One new agent was coupled to antibodies and showed high delivery to antigen on bench tests, indicating hope for development of targeted contrast agents for functional MRI. This project will focus on continued development including chemical synthesis, purification, chemical and magnetic characterization, in vivo animal studies, and antibody targeting of the agents in vivo.
* information listed above is at the time of submission.