IMPROVED MRI CONTRAST AGENTS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43CA094495-01
Agency Tracking Number: CA094495
Amount: $185,313.00
Phase: Phase I
Program: SBIR
Awards Year: 2002
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
NANOPROBES, INC.
NANOPROBES, INC., 95 HORSEBLOCK RD, YAPHANK, NY, 11980
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 JAMES HAINFELD
 (631) 205-9490
 HAINFELD@NANOPROBES.COM
Business Contact
 JAMES HAINFELD
Phone: (631) 205-9490
Email: HAINFELD@NANOPROBES.COM
Research Institution
N/A
Abstract
A new class of MRI contrast agents has been discovered and synthesized by Nanoprobes. Initial MRI animal studies showed excellent definition of some types of brain tumors, which were undetectable with the commonly used agent, gadodiamide. Furthermore, initial toxicity studies showed the agents to be non-toxic. One new agent was coupled to antibodies and showed high delivery to antigen on bench tests, indicating hope for development of targeted contrast agents for functional MRI. This project will focus on continued development including chemical synthesis, purification, chemical and magnetic characterization, in vivo animal studies, and antibody targeting of the agents in vivo.

* information listed above is at the time of submission.

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