IMPROVED MRI CONTRAST AGENTS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$185,313.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43CA094495-01
Award Id:
59895
Agency Tracking Number:
CA094495
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
NANOPROBES, INC., 95 HORSEBLOCK RD, YAPHANK, NY, 11980
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
JAMESHAINFELD
(631) 205-9490
HAINFELD@NANOPROBES.COM
Business Contact:
JAMESHAINFELD
(631) 205-9490
HAINFELD@NANOPROBES.COM
Research Institute:
n/a
Abstract
A new class of MRI contrast agents has been discovered and synthesized by Nanoprobes. Initial MRI animal studies showed excellent definition of some types of brain tumors, which were undetectable with the commonly used agent, gadodiamide. Furthermore, initial toxicity studies showed the agents to be non-toxic. One new agent was coupled to antibodies and showed high delivery to antigen on bench tests, indicating hope for development of targeted contrast agents for functional MRI. This project will focus on continued development including chemical synthesis, purification, chemical and magnetic characterization, in vivo animal studies, and antibody targeting of the agents in vivo.

* information listed above is at the time of submission.

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