Nanogold-Enhanced Radiosurgery for Malignant Brain Tumors

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$168,449.00
Award Year:
2008
Program:
SBIR
Phase:
Phase I
Contract:
1R43CA134074-01
Award Id:
88926
Agency Tracking Number:
CA134074
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
NANOPROBES, INC., 95 HORSEBLOCK RD, YAPHANK, NY, 11980
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
784163446
Principal Investigator:
() -
Business Contact:
() -
hainfeld@nanoprobes.com
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): This proposal builds on the unprecedented success achieved by our earlier studies in safely ablating malignant EMT-6 carcinomas in the thighs of mice by using photoactivation radiosurgery mediated by gold nanoparticles (so-called metal-enhanced radiosurgery [MERS]). MERS will be tested for its safety and efficacy in palliating imminently lethal brain tumors [transgenic v-src malignant gliomas] in mice. As the latter is a neuropathologically documented murine model of hum an malignant gliomas, it is expected that the proposed study will quickly and economically test the postulate that MERS shows promise to contribute to the palliation of some recurrent human gliomas by greatly decreasing the brain tumor burden, thereby enha ncing the effectiveness of adjunct drugs and immunotherapies. Tested positive in mice, positive follow-up tests in rats bearing malignant gliomas and satisfactory normal-tissue tolerance tests in fewer large animals (e.g., dogs) would then enable MERS to b e brought to clinical trials. PUBLIC HEALTH RELEVANCE: Malignant brain tumors have poor prognoses and new treatments are needed. Here we present a new treatment using gold nanoparticles that enables image guidance of focused irradiation and even magnificat ion of the dose to malignant brain tumors which, if successful, could significantly improve survival.

* information listed above is at the time of submission.

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