PROTON MICROPROBE FOR TRACE ELEMENT ANALYSIS IN TISSUE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1990
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
11358
Agency Tracking Number:
11358
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2425 Nw 26 Pl, Gainesville, FL, 32605
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
RECENT PROTON MICROPROBE STUDIES ON TRACE ELEMENTS IN SEVERAL HUMAN DISORDERS HAVE SHOWN THE SUPERIORITY OF THE PROTON AS COMPARED TO THE ELECTRON MICROPROBE. THIS HAS BEEN DRAMATICALLY DEMONSTRATED IN STUDIES OF ALUMINUM IN ALZHEIMER'S DISEASE. THE REASON FOR THE PROTON BEAM'S SUPERIORITY IS THE SUPPRESSION OF BACKGROUND X-RAY GENERATION WHEN LOOKING AT X-RAYS CHARACTERISTIC OF THE TRACE ELEMENTS. IT IS DESIRABLE TO HAVE A 2-MEV PROTON BEAM WITH 0.3-MICRON RESOLUTION (COMPARABLE TO AN ELECTRON MICROPROBE) WITH AT LEAST 100 PICOAMPERES OF CURRENT FOR THE TECHNIQUE OF PROTON-INDUCED X-RAY EMISSION. PRELIMINARY CALCULATIONS OF THE SECOND ORDER HAVE BEEN MADE FOR A FOCUSING SYSTEM TO MEET THESE CRITERIA. MEASUREMENTS HAVE ALSO BEEN MADE OF BEAM CURRENT FROM AN ACCELERATOR TO SHOW THAT THE DESIRED CURRENT CAN BE OBTAINED WITHIN THE CALCULATED FOCUSING SYSTEM ACCEPTANCE. WORK CARRIED OUT DURING PHASE I WILL SIMULATE PROTON TRAJECTORIES THROUGH THE PROPOSED FOCUSING SYSTEM TO ALL ORDERS AND, HENCE, FIRMLY ESTABLISH THE MERIT AND TECHNICAL FEASIBILITY OF THE TECHNIQUE. THE EFFECTS OF ABERRATIONS, MISALIGNMENTS, AND MANUFACTURING TOLERANCES WILL BE CALCULATED. AT PRESENT, THERE IS NO COMMERCIAL PRODUCTION OF PROTON MICROPROBES.

* information listed above is at the time of submission.

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